Figure 3.

Pulmonary microvascular endothelial cells are important in the JCAD-deletion-derived reduction in pro-inflammatory and pro-angiogenic phenotypes. (A) mRNA expression levels of KIAA1462/JCAD in various lung cell lines (n = 3 per group). (B) JCAD immunostaining in lung section of WT mice; positive cells are indicated as red arrows. (C) mRNA expression levels of TNF-α, IL-6 (interleukin-6), and CXCL8 (CXC motif chemokine ligand 8) in HPMECs with JCAD knockdown before 6 h of TNF-α treatment (n = 4 per group). Data are presented as mean ± S.E.M. *, <0.05; ***, <0.005; ns, not significant.