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. 2024 Aug 24;25(17):9199. doi: 10.3390/ijms25179199

Figure 12.

Figure 12

Furin inhibitors from WO/2019/215341. A1, A2, and A3 are each independently N or CH, wherein one or two of A1, A2, and A3 are N; X2a is NR10b or C(R11a)R12a; R1c is hydrogen; R3a and R3b are each independently F or Cl; R6a is H, F, Cl, or Me; R10a is hydrogen, (C1-C4)alkyl, or (C3-C6)cycloalkyl, which is optionally substituted by -CO2H, -CONH2, -CONH(C1-C4)alkyl, -CON((C1-C4)alkyl)((C1-C4)alkyl), OH, O(C1-C4)alkyl, -SO2(C1-C4)alkyl, or -SO2NH2; or R10a and R1c taken together represent -CH2- or -(CH2)2-; R10b is (C1-C4)alkyl, which is optionally substituted by -CONH2, -CONH(C1-C4)alkyl, or -CON((C1-C4)alkyl)((C1-C4)alkyl); R11a is (C1-C4)alkyl or (C1-C4)alkoxy, each of which is optionally substituted by one or two substituents independently selected from -CO2H, -CONH2, -CONH(C1-C4)alkyl, -CON((C1-C4)alkyl)((C1-C4)alkyl), OH, -OCONH(C1-C4)alkyl, -NHCO(C1-C4)alkyl, -NHCO2(C1-C4)alkyl, and -NHCONH(C1-C4)alkyl; R12a is H, OH, or F. When R12a is OH, R11a is (C1-C4)alkyl, which is optionally substituted by one or two substituents independently selected from -CO2H, -CONH2, -CONH(C1-C4)alkyl, -CON((C1-C4)alkyl)((C1-C4)alkyl), OH, -OCONH(C1-C4)alkyl, -NHCO(C1-C4)alkyl, -NHCO2(C1-C4)alkyl, and -NHCONH(C1-C4)alkyl; and m is 1 or 2.