Table 17.

Activity and toxicity of non-covalent polypeptide inhibitors of furin in mice.

No. [Ref.]	Structural Formula	Ki, pM	In mice
			Tolerated Dose, mg/kg	Number of Deaths at Next Higher Dose a
1 (MI-1148) [153,158]		5.5	2.5	4 of 4 at 5 mg/kg
2 [153,158]		8.8	5	4 of 4 at 10 mg/kg
5 [158]		114	15	higher dose not tested
6 [158]		36.3	10	1 of 4 at 15 mg/kg
8 (MI-1851) [151,158]		10.1	15	higher dose not tested
17 [164]		7.08	15	1 of 4 at 20 mg/kg

^a In each group, four mice (2 female and 2 male) were IP treated.