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. 2024 Aug 24;25(17):9199. doi: 10.3390/ijms25179199

Table 18.

Compound effects of furin inhibitors on mouse lung TGFβ and hydroxyproline content in the bleomycin-induced lung fibrosis mouse model. The % inhibition is presented at a once-daily frequency dose of 10 mg/kg drug relative to the levels induced by bleomycin in animals treated with placebo (Data taken from [95]).

No. [90] Furin Inhibitor pIC50/IC50 Route % Inhibition in Lung of *
TGFβ Hydroxyproline
137 graphic file with name ijms-25-09199-i014.jpg 9.1/0.8 nM Oral 81 54
207, BOS-318 graphic file with name ijms-25-09199-i015.jpg 9.1/0.8 nM Oral 66 46
263 graphic file with name ijms-25-09199-i016.jpg 9.8/0.16 nM IP 86 60

* t-test: p < 0.05.