Figure 5.

Effects of drugs on the levels of various proteins involved in DNA repair/DNA damage response. Cells were exposed to the indicated drug concentrations for 3 days prior to analysis by Western blotting. For the double- and triple-drug combinations, the drug concentrations were the same as indicated in the single-drug concentrations. Number of replicates = 3; DSB: double-strand break; HR: homologous recombination; NHEJ: non-homologous DNA end-joining; NuRD: nucleosome remodeling and deacetylase. Pano: panobinostat; SAHA: vorinostat; TLZ: talazoparib; Ola: olaparib; DAC: decitabine.