Figure 5.

The concentration–time profiles of F26 after a single IV administration. Each plasma (A) and brain (B) sample was collected after IV administration of NP F26 at 51 mg/kg dose in three-month-old WT mice and was analyzed via LC-MS/MS. Individual points represent mean ± SD for two independent animals (n = 2). The pharmacokinetic analyses were performed using a non-compartmental analysis, and the parameters are shown in the inserted tables. Data are presented as mean. C_max, maximum concentration; T_max, time to maximum concentration; AUC_last, area under the concentration–time curve from zero to final observation time; T_1/2, elimination half-life.