Table 2.

CD147-based therapies for hematological malignancies.

Name	Mechanism of Action	Cell Lines/Tumor Xenograft	Effects	References
siRNA	Silencing	AML cell line	Inhibits leukemic cell proliferation and increases chemosensitivity to Adriamycin	[132]
siRNA	Silencing	Lymphoma cell line	Increases chemosensitivity	[144]
AC-73	Disrupts CD147 dimerization	Cell lines and primary AML blasts	Inhibits leukemic cell proliferation and increases chemosensitivity to ARA-C and ATO	[15]
PAB	CD147 inhibitor	Cell lines and primary AML blasts	AML cell apoptosis	[43]
h4#147D	Humanized anti-CD147 antibody	Xenograft CML mouse models	Strong antitumor effects with tumour regression	[90]
MEM-M6/6	Monoclonal CD147 antibodies (mAbs)	CML cell line	Decreased expression of CD147 and causes downregulation of P-gp	[134]
CD147-CAR T cells	(CAR) T-cell therapy	T-ALL cell line and T-ALL blasts	Antitumor activity	[143]