Table 2.

CHC levels in response to treatment and during post-trial surveillance.

	Trial-Directed Therapy		Post-Trial Surveillance
	CHC Level Nadir after Treatment Initiation	CHC Levels by End of Treatment	Evidence of Progression	CHC Levels
Patient 2	Undetectable	Undetectable	Yes	Increased
Patient 3	Undetectable	Undetectable	No	Undetectable
Patient 4	Undetectable	Undetectable	Yes	Increased
Patient 1	Undetectable	Increased	N/A	N/A
Patient 5	Undetectable	Increased	Yes	Increased

Abbreviations: CHC, circulating hybrid cells. Response and resistance determined by multidisciplinary interpretation of standard-of-care carbohydrate antigen (CA) 19-9 and cross-sectional imaging measures (Figure S2) for each patient.