Figure 1.

Scheme of our overall workflow including, all earlier and current research. The focus of our current study is the proof-of-concept step IV in children (red frame) with different kinds of CKD. Steps I (mice), II (dogs) and—in parts—III (children) have been published in [49,50]. Abbreviations: ACI, angiotensinogen converting enzyme inhibition; TBMN, thin basement membrane nephropathy; BFH, benign familial hematuria; DM, diabetes mellitus; CAKUT, congenital anomalies of kidney and urinary tract; ADPKD and ARPKD, autosomal dominant and recessive polycystic KDs; IgAN, IgA-nephropathy; GN, glomerulonephritis.