Table 3.

ROC analysis and comparison of urine BM values from patients with ADPKD and ARDKD (group E) with healthy controls. ROC analysis by SPSS (cf. Methods section). Only BMs with AUC >0.600 are shown. Misclassification rate = (false positives + false negatives)/total sample counts, determined at the cut-off given. For abbreviations, see Table 1 and Table 2. Concentration ranges of BMs: ng/mg creatinine: ADP, AGT, ColXIII, HABP2, C4BP, CFH, CFI, FGG, GS, LRGP1, VTN, C1q; pg/mg creatinine: CRP, C9, FMN, PICP, TGF-β. Products of BM concentrations were built as in Figure 4.

BM	Cut-off	Sensitivity	1-Specificity	AUC	95%—Confidence Interval	Misclassification Rate	BM × BM	Cut-off	Sensitivity	1-Specificity	AUC	95%—Confidence Interval	Misclassification Rate
ColXIII	0.07	0.857	0.36	0.717	0.624–0.810	0.34	ADP × PICP	260.4	0.500	0.061	0.727	0.536–0.918	0.11
HABP2	0.29	0.636	0.194	0.744	0.595–0.894	0.21	AGT × GS	115.3	0.500	0.146	0.754	0.592–0.916	0.48
C4BP	3.46	0.692	0.240	0.693	0.512–0.874	0.27	AGT × C9	245.8	0.600	0.073	0.754	0.571–0.938	0.10
CRP	7.54	0.529	0.149	0.656	0.495–0.818	0.20	C4BP × ColXIII	0.53	0.667	0.235	0.750	0.603–0.897	0.27
CFH	8.89	0.667	0.313	0.697	0.542–0.853	0.31	GS × CFH	624.0	0.700	0.253	0.754	0.589–0.918	0.26
CFI	1.70	0.462	0.131	0.669	0.496–0.842	0.14	GS × C9	19728	0.600	0.091	0.754	0.581–0.926	0.12
							GS × CFI	184.1	0.700	0.111	0.796	0.635–0.958	0.13
							HABP2 × TGFβ	3.28	0.700	0.133	0.755	0.569–0.941	0.15
							HABP2 × FGG	365.4	0.700	0.092	0.812	0.678–0.947	0.11
							VTN × CFI	4.83	0.667	0.101	0.765	0.576–0.954	0.07
							CFH × CFI	27.3	0.636	0.152	0.762	0.599–0.925	0.17
							CFI × FGG	2883	0.583	0.040	0.755	0.586–0.924	0.08
							CFH × FGG	9180	0.727	0.232	0.771	0.610–0.931	0.14
							C4BP × ColXIII × HABP2	0.11	0.700	0.156	0.784	0.626–0.942	0.17