Figure 2.

Cholesterol levels of mice with wild-type/knocked-out CB₁R and LDLR kept on a control diet or a high-fat diet (one-way ANOVA with Holm–Sidak comparisons and two-way ANOVA with Bonferroni post hoc test) (**, p = 0.006 and ***, p < 0.001 between CD and HFD groups) (#, p = 0.013; ##, p = 0.002; and ###, p < 0.001 between LDLR+/+ and LDLR−/− groups) (n = 3–5). Mean ± SEM values are indicated here, with dots showing individual data points. Abbreviations: CD, control diet; HFD, high-fat diet; CB₁R, cannabinoid type 1 receptor; CB₁R+/+, endocannabinoid type 1 receptor wild type; CB₁R−/−, endocannabinoid type 1 knockout; LDLR, low-density lipoprotein receptor; LDLR+/+, low-density lipoprotein receptor wild type; LDLR−/−, low-density lipoprotein receptor knockout.