Table 3.
Association between high-sensitivity CRP and low cognitive function (70-year-old group)
| Q1 | Q2 | Q3 | Q4 | ||
|---|---|---|---|---|---|
| (0.050–0.160 mg/L) | (0.161–0.364 mg/L) | (0.365–0.720 mg/L) | (0.727–7.420 mg/L) | p for trend | |
| Number | 103 | 103 | 103 | 103 | |
| MoCA-J score, mean (SD) | 24.2 (2.7) | 24.0 (3.4) | 24.2 (3.1) | 22.8 (3.1) | |
| Low cognitive function, n (%) | 66 (64.1) | 71 (68.9) | 66 (64.1) | 85 (82.5) | |
| Model 1a | |||||
| OR (95% CI) | 1 (ref.) | 1.24 (0.69–2.21) | 1.02 (0.57–1.80) | 2.63 (1.38–5.04) | 0.013 |
| p-value | 0.475 | 0.957 | 0.003 | ||
| Model 2b | |||||
| OR (95% CI) | 1 (ref.) | 1.16 (0.64–2.10) | 0.88 (0.49–1.58) | 2.47 (1.28–4.78) | 0.031 |
| p-value | 0.626 | 0.671 | 0.007 | ||
| Model 3c | |||||
| OR (95% CI) | 1 (ref.) | 1.20 (0.65–2.19) | 0.96 (0.53–1.76) | 2.56 (1.30–5.02) | 0.023 |
| p-value | 0.561 | 0.894 | 0.006 |
Notes: CRP = C-reactive protein, MoCA-J = Japanese version of the Montreal Cognitive Assessment, IMT = Intima-media thickness, OR = Odds ratio, CI = Confidence interval, Q = Quartile, SD = Standard deviation
aAdjusted for sex; bModel 1 + education and smoking; cModel 2 + hypertension, diabetes mellitus, dyslipidemia, and mean IMT