Table 4.
Association between high-sensitivity CRP and low cognitive function (80-year-old group)
| Q1 | Q2 | Q3 | Q4 | ||
|---|---|---|---|---|---|
| (0.050–0.212 mg/L) | (0.214–0.404 mg/L) | (0.409–0.892 mg/L) | (0.911–9.890 mg/L) | p for trend | |
| Number | 115 | 115 | 115 | 115 | |
| MoCA-J score, mean (SD) | 22.3 (3.9) | 22.2 (3.6) | 21.9 (3.5) | 21.6 (3.9) | |
| Low cognitive function, n (%) | 83 (72.2) | 97 (84.3) | 95 (82.6) | 97 (84.3) | |
| Model 1a | |||||
| OR (95%CI) | 1 (ref.) | 2.09 (1.09–4.01) | 1.84 (0.98–3.47) | 2.09 (1.09–4.00) | 0.034 |
| p-value | 0.026 | 0.058 | 0.026 | ||
| Model 2b | |||||
| OR (95%CI) | 1 (ref.) | 2.33 (1.20–4.52) | 1.96 (1.03–3.74) | 2.54 (1.29–5.00) | 0.011 |
| p-value | 0.013 | 0.040 | 0.007 | ||
| Model 3c | |||||
| OR (95%CI) | 1 (ref.) | 2.40 (1.19–4.82) | 1.83 (0.93–3.60) | 2.27 (1.14–4.55) | 0.038 |
| p-value | 0.014 | 0.080 | 0.020 |
Notes: CRP = C-reactive protein, MoCA-J = Japanese version of the Montreal Cognitive Assessment, IMT = Intima-media thickness, OR = Odds ratio, CI = Confidence interval, Q = Quartile, SD = Standard deviation
aAdjusted for sex, bModel 1 + education and smoking, cModel 2 + hypertension, diabetes mellitus, dyslipidemia, and mean IMT