Table 3.
Hormonal profile in the control group, the group of patients with idiopathic hirsutism, and the group of patients with PCOS.
| Controls (n = 20) |
Women with IH (n = 12) |
Women with PCOS (n = 10) | p-Value | Multiple Comparison | |
|---|---|---|---|---|---|
| AMH [ng/mL] | 2.52 (2.11–3.53) | 2.14 (0.83–3.62) | 8.53 (6.14–10.95) | 0.000 | C, H<P |
| SHBG [nmol/L] | 68.9 (51.8–91.3) | 57.3 (48.8–64.7) | 44.3 (27.4–75.3) | 0.131 | |
| LH [IU/L] | 6.6 (5.5–8.0) | 7.1 (4.9–9.5) | 9.3 (7.0–11.6) | 0.082 | |
| FSH [IU/L] | 7.1 (5.5–9.0) | 5.9 (5.1–7.5) | 6.1 (3.3–7.3) | 0.509 | |
| LH/FSH | 0.83 (0.69–1.13) | 1.21 (0.85–1.55) | 1.71 (1.53–2.21) | <0.001 | C, H<P |
| Pregnenolone [ng/mL] | 0.995 (0.577–1.274) | 1.441 (0.901–2.670) | 1.182 (0.856–2.295) | 0.170 | |
| 17OHPreg [ng/mL] | 5.495 (3.669–11.617) | 5.565 (2.550–6.748) | 9.105 (3.226–13.095) | 0.282 | |
| Progesterone [ng/mL] | 0.123 (0.098–0.185) | 0.098 (0.098–0.098) | 0.098 (0.098–0.295) | 0.400 | |
| 17OHProg [ng/mL] | 0.433 (0.367–0.517) | 0.503 (0.340- 0.695) | 0.839 (0.560–0.882) | 0.011 | C, H<P |
| 11DOF [ng/mL] | 0.282 (0185–0.611) | 0.310 (0.185–0.540) | 0.630 (0.211–0.884) | 0.451 | |
| 11DOC [ng/mL] | 0.022 (0.014–0.042) | 0.014 (0.014–0.031) | 0.030 (0.014–0.075) | 0.547 | |
| Cortisol [ng/mL] | 188 (138–231) | 197 (165–225) | 177 (132–286) | 0.727 | |
| Cortisone [ng/mL] | 42.74 (40.05–47.16) | 44.58 (37.56–51.81) | 46.52 (39.50–49.73) | 0.989 | |
| Corticosterone [ng/mL] | 2.099 (1.237–4.38) | 2.452 (1.544–3.029) | 3.289 (1.237–6.82) | 0.574 | |
| Aldosterone [ng/mL] | 0.134 (0.068–0.179) | 0.092 (0.055–0.148) | 0.126 (0.108–0.255) | 0.758 | |
| DHEA [ng/mL] | 7.64 (4.63–11.53) | 6.28 (5.05–8.33) | 12.62 (7.85–16.12) | 0.041 | H<P |
| T [ng/mL] | 0.235 (0.202–0.269) | 0.229 (0.096–0.301) | 0.362 (0.264–0.460) | 0.015 | C, H<P |
| Free T [pmol/L] | 25.2 (21.4–35.9) | 32.3 (26.1–46.7) | 46.8 (36.8–59.4) | 0.003 | C<P |
| Epitestosterone [ng/mL] | 0.005 (0.004–0.010) | 0.007 (0.003–0.010) | 0.014 (0.009–0.018) | 0.003 | C, H<P |
| A4 [ng/mL] | 1.195 (0.945–1.431) | 1.135 (0.643–1.638) | 2.119 (1.706–2.625) | 0.001 | C, H<P |
| DHT [ng/mL] | 0.098 (0.066–0.118) | 0.066 (0.066–0.076) | 0.102 (0.086–0.133) | 0.045 | H<C, P |
| 11βOHA4 [ng/mL] | 0.701 (0.414–0.908) | 0.458 (0.325–0.631) | 1.029 (0.527–1.404) | 0.036 | H<P |
| 11KT [ng/mL] | 0.407 (0.329–0.503) | 0.303 (0.191–0.396) | 0.483 (0.325–0.647) | 0.022 | H<C, P |
| 11OHT [ng/mL] | 0.138 (0.100–0.148) | 0.085 (0.060–0.113) | 0.145 (0.088–0.226) | 0.027 | H<C, P |
| 7αOHDHEA [ng/mL] | 0.358 (0.228–0.596) | 0.285 (0.223–0.326) | 0.565 (0.328–0.632) | 0.017 | H<C, P |
| 7βOHDHEA [ng/mL] | 0.148 (0.066–0.200) | 0.098 (0.081–0.136) | 0.201 (0.158–0.257) | 0.031 | H<P |
| 7KDHEA [ng/mL] | 0.083 (0.065–0.110) | 0.062 (0.045–0.078) | 0.102 (0.079–0.116) | 0.005 | H<C, P |
| Estrone [ng/mL] | 0.033 (0.026–0.037) | 0.028 (0.022–0.052) | 0.047 (0.035–0.057) | 0.031 | C, H<P |
| 17β-Estradiol [ng/mL] | 0.021 (0.016–0.030) | 0.027 (0.015–0.037) | 0.023 (0.021–0.030) | 0.818 |
Abbreviations in multiple comparisons: C—controls, H—women with IH, P—women with PCOS. Abbreviations of hormones: AMH—Anti-Müllerian hormone; SHBG—sex hormone binding globulin; FSH—follicle-stimulating hormone; LH—luteinizing hormone; 17OHPreg—17-hydroxypregnenolone; 11DOC—11-deoxycorticosterone; 17OHProg—17-hydroxyprogesterone; 11DOF—11-deoxycortisol; 21DOF—21-deoxycortisol; DHEA—dehydroepiandrosterone; T—testosterone; A4—androstenedione; DHT—dihydrotestosterone; 11βOHA4—11β-hydroxyandrostenedione; 11KT—11-ketotestosterone; 11OHT—11β-hydroxytestosterone; 7αOHDHEA—7α-hydroxydehydroepiandrosterone; 7βOHDHEA—7β-hydroxydehydroepiandrosterone; 7KDHEA—7-ketodehydroepiandrosterone. p-values lower than 0.05 are marked in bold.