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Serous tubal intraepithelial carcinoma (STIC) and high-grade serous carcinoma (HGSC). (A). Serous tubal intraepithelial carcinoma (STIC) with irregular luminal surface, and stratified epithelium (contrast with normal mucosa). (B,C). High-grade serous carcinoma (HGSC) invades omentum (peritoneal) and displays solid architecture. (D). p53 staining in peritoneal metastasis: strong and diffuse expression in tumor cell nuclei (>90%), corresponding to p53 missense mutation.
