Table 3.
Association of renal function with incidence of diabetes mellitus in impaired glucose tolerance group.
| Number of Participants | Number of Events | Event Rate (%) (95% CI) |
Person-Years | Incidence Rate (Per 1000 Person-Years) |
Adjusted HR (95% CI) |
p-Value | |
|---|---|---|---|---|---|---|---|
| eGFR (decile) | |||||||
| 1st (<66.24) | 55,212 | 10238 | 18.54 (18.22, 18.87) |
465,420.58 | 21.99 | 1.16 (1.13, 1.19) |
<0.001 |
| 2nd (66.26–73.51) | 55,438 | 8902 | 16.06 (15.75, 16.36) |
486,498.62 | 18.30 | 1.15 (1.12, 1.19) |
<0.001 |
| 3rd (73.61–78.86) | 55,506 | 8025 | 14.46 (14.17, 14.75) |
493,785.82 | 16.25 | 1.14 (1.11, 1.18) |
<0.001 |
| 4th (78.96–83.58) | 55,874 | 7733 | 13.93 (13.64, 14.22) |
492,762.15 | 15.69 | 1.09 (1.05, 1.12) |
<0.001 |
| 5th (83.70–88.35) | 55,781 | 7205 | 12.92 (12.64, 13.20) |
498,780.04 | 14.45 | 1 (ref) | |
| 6th (88.40–92.81) | 55,180 | 8285 | 15.01 (14.72, 15.31) |
488,715.31 | 16.95 | 1.20 (1.16, 1.24) |
<0.001 |
| 7th (92.86–97.85) | 56,860 | 8045 | 14.15 (13.86, 14.44) |
507,916.24 | 15.84 | 1.18 (1.15, 1.22) |
<0.001 |
| 8th (98.1–102.79) | 54,239 | 7121 | 13.13 (12.85, 13.41) |
487,489.01 | 14.61 | 1.15 (1.11, 1.19) |
<0.001 |
| 9th (102.95–109.80) | 55,205 | 5563 | 10.08 (9.83, 10.33) |
503,830.77 | 11.04 | 0.94 (0.91, 0.97) |
<0.001 |
| 10th (≥109.91) | 55,701 | 3820 | 6.86 (6.65, 7.07) |
514,763.91 | 7.42 | 0.66 (0.62, 0.69) |
<0.001 |
| eGFR (range) | |||||||
| <30 | 407 | 90 | 22.11 (18.08, 26.14) |
2569.83 | 35.02 | 1.26 (1.02, 1.55) |
0.029 |
| 30–60 | 25861 | 4873 | 18.84 (18.37, 19.32) |
210,372.17 | 23.16 | 0.99 (0.97, 1.03) |
0.867 |
| 60–90 | 274,358 | 39,866 | 14.53 (14.40, 14.66) |
2,428,359.27 | 16.42 | 1 (ref) | |
| 90–120 | 241,347 | 29,308 | 12.14 (12.01, 12.27) |
2,177,657.39 | 13.46 | 0.96 (0.95, 0.98) |
<0.001 |
| >120 | 13,023 | 800 | 6.14 (5.73, 6.56) |
121,003.79 | 6.61 | 0.55 (0.51, 0.59) |
<0.001 |
CI, confidence interval; HR, hazard ratio; eGFR, estimated glomerular filtration rate.