Table 5.
Characteristics of the sample.
| Hospital Clinic of Barcelona | Mayo Clinic | |||
|---|---|---|---|---|
| Acute Phase | Response | Acute Phase | Response | |
| Total patients recruited | ||||
| Manic Episode (acute phase) N (%) | 13 (20) | 9 (69.2) | 11 (100) | 8 (73) |
| Major Depressive Episode (acute phase) N (%) | 21 (32.3) | 9 (42.9) | ||
| Euthymia N (%) | 31 (47.7) | |||
| Total N (%) | 65 (100) | 11 (100) | ||
| Symptoms and functional variables | ||||
| Patients with acute episodes | ||||
| YMRS score (manic patients only) (M ± SD) | 24 ± 8.5 | 5.9 ± 6.2 | 21.7 ± 5 | 4.6 ± 4.3 |
| HDRS-17 score (depressed patients only) (M ± SD) | 17.1 ± 4.4 | 3.3 ± 2.8 | ||
| PANSS positive symptoms score (M ± SD) | 11.0 ± 7.3 | 8.5 ± 3.0 | ||
| PANSS negative symptoms score (M ± SD) | 12.1 ± 5.1 | 9.7 ± 4.5 | ||
| PANSS general symptoms score (M ± SD) | 27.3 ± 5.5 | 21.2 ± 4.2 | ||
| PANSS total symptoms score (M ± SD) | 50.4 ± 10.6 | 39.4 ± 7.8 | ||
| CGI-S score (M ± SD) | 4.3 ± 0.9 | 2.4 ± 1.3 | ||
| SOFAS score (M ± SD) | 50.0 ± 13.0 | 69.1 ± 23.9 | ||
| Euthymic patients | ||||
| YMRS score (M ± SD) | 0.97 ± 1.4 | |||
| HDRS-17 score (M ± SD) | 3.9 ± 2.9 | |||
| PANSS positive symptoms score (M ± SD) | 7.0 ± 0.2 | |||
| PANSS negative symptoms score (M ± SD) | 8.7 ± 3.1 | |||
| PANSS general symptoms score (M ± SD) | 19.6 ± 3.2 | |||
| PANSS total symptoms score (M ± SD) | 35.3 ± 5.2 | |||
| CGI-S score (M ± SD) | 1.7 ± 0.7 | |||
| SOFAS score (M ± SD) | 78.8 ± 9.9 | |||
| Sociodemographic and clinical variables | ||||
| Age (M ± SD) | 48.1 ± 13.3 | 33.6 ± 14.5 | ||
| Sex: Females N (%) | 42 (64.6) | 6 (54.5) | ||
| Age of Onset (M ± SD) | 32.9 ± 10.9 | 26.8 ± 12.2 | ||
| Illness Duration (years) (M ± SD) | 14.9 ± 12.6 | 7.8 ± 7.3 | ||
| Number of Previous Affective Episodes (Median, IQR) | 1, 1–2 | 4, 2–6 | ||
| Psychotic Features (patients on acute episodes only) N (%) | 9 (24.3) | 0 (0.0) | ||
| Anxious Features (patients on acute episodes only) N (%) | 29 (78.4) | 11 (100.0) | ||
| Mixed Features (patients on acute episodes only) N (%) | 9 (24.3) | 6 (54.5) | ||
| Active Suicidality (patients on acute episodes only) N (%) | 12 (32.4) | 3 (27.3) | ||
| Non-Psychiatric Medical Comorbidities N (%) | 44 (67.7) | 10 (90.9) | ||
| Psychiatric Comorbidities N (%) | 10 (15.4) | 9 (81.8) | ||
| Past Drug Use N (%) | 14 (21.5) | 6 (54.5) | ||
| Current Drug Use N (%) | 15 (23.1) | 7 (63.6) | ||
| Setting | ||||
| Outpatient N (%) | 52 (80) | 4 (13) | ||
| Psychopharmacological Treatment | ||||
| Antipsychotics N (%) | 46 (70.8) | 11 (100) | ||
| Lithium N (%) | 41 (63.1) | 7 (63.6) | ||
| Other Mood Stabilizers N (%) | 29 (44.6) | 5 (45.4) | ||
| Antidepressants N (%) | 23 (38.5) | 1 (9.0) | ||
| Benzodiazepines N (%) | 32 (49.2) | 8 (0.72) | ||