a, Data sources of genome-wide association studies (GWAS) included in PGC-PTSD Freeze 3. Collections of contributing studies are pictured as bubble plots where each circle represents a contributing study. Circle areas are proportional to sample size and colors indicate the ancestry classification of participants (blue, EA; red, AA; purple, LAT). Arrowed lines indicate data sources being pooled together to perform GWAS meta-analyses stratified by ancestry. b, Methods applied for genetic characterization of PTSD, gene prioritization analyses, and translational applications. Abbreviations: EA, European ancestry, AA, African ancestry, LAT, Native American (Latin American) ancestry; EHR, electronic health record