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. Author manuscript; available in PMC: 2024 Sep 13.
Published in final edited form as: Nat Genet. 2024 Apr 18;56(5):792–808. doi: 10.1038/s41588-024-01707-9

Extended Data Figure 5: MAGMA cell-type enrichment analysis in midbrain.

Extended Data Figure 5:

MAGMA gene-property analysis of 25 midbrain cell types (GSE76381) indicate enrichment of GABAergic neurons, GABAergic neuroblasts, and mediolateral neuroblasts. Vertical bars depict -log10 p-values. Significant cell types are colored blue and grey if not. The dotted horizontal line indicates statistical significance adjusted for the number of comparisons (p < 0.05/25). The asterisk (*) indicates that GABAergic neurons remained significant in stepwise conditional analysis of the other significant cell types. Abbreviations: Gaba - GABAergic neurons; NbGaba - neuroblast gabaergic; NbML1–5, mediolateral neuroblasts; DA0–2 - dopaminergicneurons; Sert, serotonergic; RN, red nucleus; Rgl 1–3, radial glia-like cells; NbM, medial neuroblast; OPC, oligodendrocyte precursor cells. ProgFPL - progenitor lateral floorplate; OMTN - oculomotor and trochlear nucleus; Endo, endothelial cells; ProgM, progenitor midline;NProg, neuronal progenitor; ProgBP, progenitorbasal plate; Mgl, microglia; ProgFPM, progenitor medial floorplate; Peric – pericytes.