Extended Data Figure 7: Genetic correlations and polygenic overlap between PTSD and other psychiatric disorders.

a, Genetic correlations (r_g) between PTSD and other psychiatric disorders are indicated by circles that are drawn along the x axis. Red dots indicate SNP based heritability (h²_SNP) z-score > 6 in the psychiatric disorder GWAS and colored grey to indicate z-score < 6 (r_g estimates may be unreliable). The first author and publication year of source summary data is noted in parenthesis following the disorder name. b, Quantification of the polygenic overlap between PTSD and other psychiatric disorders. Euler diagrams depict Bivariate MiXeR analysis of PTSD (blue circles) and bipolar disorder (BIP), major depression (MDD), and schizophrenia (SCZ) (red circles). Values in the overlapping part of the Euler diagrams denote shared polygenicity (expressed as the number of influential variants, in thousands, with SE in parenthesis), and values in the non-overlapping part indicate dataset-specific variation. r_g between dataset pairs are noted in the boxes below the Euler plots. Abbreviations: ADHD, attention deficit hyperactive disorder; alc. dep, alcohol dependence; BIP, bipolar disorder; MDD, major depression; OCD, obsessive compulsive disorder; SCZ, schizophrenia.