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. Author manuscript; available in PMC: 2024 Sep 13.
Published in final edited form as: Nat Genet. 2024 Apr 18;56(5):792–808. doi: 10.1038/s41588-024-01707-9

Figure 3 |. Manhattan plots of PTSD associations in multi-omic analyses.

Figure 3 |

a,b, Gene expression data from 13 brain tissue types and the pituitary were used to conduct transcriptome-wide association study (TWAS) identifying 9 loci with differential expression between PTSD cases and controls (a) and expression quantitative trait locus summary based Mendelian randomization (eQTL SMR) identifying 4 loci where gene expression has putative causal effects on PTSD (b). c, Blood protein quantitative trait locus (pQTL) SMR identify 16 blood proteins whose abundance has a putative causal effect on PTSD. The y-axis refers to −log10 P-values from two-sided z-tests for TWAS, two-sided Chi-square tests for eQTL SMR, and two-sided Chi-square tests for pQTL SMR. The horizontal red bars indicate gene-wide significance (P < 0.05/14,935 for TWAS, P < 0.05/9,903 for eQTL SMR, and P < 0.05/1,209 for pQTL SMR). Significant findings are labeled.