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. Author manuscript; available in PMC: 2024 Sep 13.
Published in final edited form as: Nat Genet. 2024 Apr 18;56(5):792–808. doi: 10.1038/s41588-024-01707-9

Figure 4 |. Gene prioritization in PTSD loci.

Figure 4 |

Summary of evidence categories of prioritized genes (Tier 1 or 2) for the top 20% of PTSD loci (as ranked by leading SNP P-value). Locus number, prioritized genes within locus, gene locations (in terms of cytogenic band), and gene tier ranks (Tier 1, orange; Tier 2, blue) are indicated on the left. Categories of evidence are grouped and colored according to the domain they belong to. CADD scores, pLI scores and fine-mapping PIPs are written within their respective squares. The total weighted scores taken across all 9 evidence categories are shown on the rightmost squares. Abbreviations: eQTL, expression QTL; CI, chromatin interaction; CADD, combined annotation dependent depletion; RDB, regulome DB; pLI, predicted loss of impact; PIP, posterior importance probability; TWAS, transcriptome-wide association study; SMR, summary Mendelian randomization; pQTL, protein QTL.