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. Author manuscript; available in PMC: 2024 Sep 13.
Published in final edited form as: Nat Genet. 2024 Apr 18;56(5):792–808. doi: 10.1038/s41588-024-01707-9

Table 1 |. Genome-wide significant loci associated with PTSD in the multi-ancestry and European PGC-PTSD Freeze 3 data.

Multi-ancestryc (150,793 cases, 1,130,197 controls) EAc (137,136 cases, 1,085,746 controls) AAc (11,560 cases, 39,474 controls) LATc (2,064 cases, 4,953 controls)
Locusa Lead SNPb Chr Start Stop A1 A2 A1 Freq Z score P-valued A1 Freq Z score P-valued A1 Freq Z score P-valued A1 Freq Z score P-valued
1 rs78201023 1 35,664,657 36,375,226 T C NA NA NA 0.038 6.264 3.76E-10 NA NA NA NA NA NA
2 rs617099 1 38,198,744 38,459,210 A T 0.692 −5.525 3.30E-08 0.713 −5.283 1.27E-07 0.386 −1.859 0.06 0.585 0.283 0.78
2 rs12026766 1 38,198,744 38,459,210 A G 0.277 5.425 5.80E-08 0.272 5.538 3.06E-08 0.329 0.358 0.72 0.399 −0.028 0.98
3 rs2186120 1 66,392,405 66,584,457 A G 0.504 5.592 2.24E-08 0.529 5.388 7.12E-08 0.146 2.314 0.02 0.422 −1.787 0.07
3 rs7519259 1 66,392,405 66,547,212 A G 0.511 5.335 9.58E-08 0.532 5.514 3.50E-08 0.198 0.665 0.51 0.426 −1.500 0.13
4 rs10789373 1 73,279,823 74,108,971 C G 0.606 −8.061 7.59E-16 0.619 −7.828 4.95E-15 0.447 −2.193 0.03 0.320 0.290 0.77
4 rs12128161 1 73,275,828 74,099,273 A C 0.608 −7.946 1.93E-15 0.615 −7.882 3.23E-15 0.539 −1.640 0.10 0.328 0.587 0.56
5 rs2207285 1 88,790,511 88,836,922 A C 0.157 −5.557 2.75E-08 0.158 −5.311 1.09E-07 0.157 −1.132 0.26 0.144 −1.610 0.11
6 rs169235 1 181,698,693 181,747,349 A G 0.747 −6.509 7.56E-11 0.751 −6.191 6.00E-10 0.702 −1.560 0.12 0.651 −1.598 0.11
6 rs4652676 1 181,698,693 181,747,349 A G 0.251 6.247 4.19E-10 0.248 6.396 1.60E-10 0.280 −0.284 0.78 0.349 1.553 0.12
7 rs9287117 1 191,154,894 191,418,368 T C 0.384 6.378 1.80E-10 0.369 6.390 1.66E-10 0.630 0.736 0.46 0.256 0.439 0.66
7 rs9651063 1 191,154,894 191,418,368 T C 0.378 6.337 2.35E-10 0.367 6.409 1.47E-10 0.553 0.602 0.55 0.253 0.181 0.86
8 rs2011374 1 214,094,735 214,139,159 A T 0.510 −6.093 1.11E-09 0.505 −5.738 9.58E-09 0.600 −0.760 0.45 0.389 −3.818 0.00
9 rs10865093 2 22,430,795 22,613,427 T C 0.545 −8.585 9.08E-18 0.541 −8.736 2.41E-18 0.645 −0.548 0.58 0.255 −0.279 0.78
9 rs6759922 2 22,430,795 22,613,427 A G 0.460 8.572 1.01E-17 0.457 8.821 1.13E-18 0.461 0.163 0.87 0.746 0.299 0.76
10 rs1866560 2 27,186,507 27,345,484 T G 0.464 −5.448 5.11E-08 0.449 −5.455 4.89E-08 0.658 −1.253 0.21 0.661 1.210 0.23
11 rs10496632 2 124,953,763 125,053,393 C G 0.282 −6.698 2.12E-11 0.286 −6.680 2.40E-11 0.206 −0.839 0.40 0.330 −0.528 0.60
12 rs6430728 2 138,097,204 138,334,702 A G 0.526 5.683 1.33E-08 0.511 5.996 2.02E-09 0.747 −0.008 0.99 0.548 −0.959 0.34
13 rs28380327 2 144,145,478 144,263,280 A T 0.657 5.593 2.23E-08 0.642 5.355 8.58E-08 0.864 1.711 0.09 0.811 0.085 0.93
13 rs10191758 2 144,145,478 144,272,229 A G 0.637 5.517 3.44E-08 0.626 5.487 4.08E-08 0.789 0.860 0.39 0.803 0.150 0.88
14 rs197261 2 161,866,881 162,095,003 A G 0.727 5.373 7.74E-08 0.718 5.994 2.05E-09 0.837 −1.129 0.26 0.851 −1.276 0.20
15 rs6800583 3 16,843,737 16,879,208 A G 0.383 6.117 9.54E-10 0.373 6.366 1.95E-10 0.541 0.157 0.88 0.360 −0.578 0.56
15 rs748832 3 16,843,737 16,879,208 A G 0.618 −5.785 7.25E-09 0.627 −6.377 1.80E-10 0.483 1.219 0.22 0.641 0.583 0.56
16 rs4373086 3 18,611,283 18,824,298 A G 0.732 5.648 1.62E-08 0.722 5.765 8.19E-09 0.878 1.166 0.24 0.758 −2.025 0.04
16 rs6800637 3 18,611,283 18,824,298 A T 0.722 5.599 2.15E-08 0.711 5.923 3.16E-09 0.853 0.520 0.60 0.747 −2.028 0.04
17 rs6801151 3 43,249,957 43,591,405 A G 0.163 6.326 2.52E-10 0.156 6.098 1.08E-09 0.275 1.860 0.06 0.065 −0.132 0.90
17 rs6802567 3 43,249,957 43,594,564 T C 0.876 −6.263 3.79E-10 0.883 −6.726 1.74E-11 0.763 0.959 0.34 0.953 −0.155 0.88
18 rs7431106 3 49,734,229 50,644,134 A G 0.491 7.941 2.00E-15 0.488 7.304 2.78E-13 0.582 3.090 0.00 0.247 1.372 0.17
18 rs11130221 3 49,734,229 50,644,134 C G 0.511 −7.792 6.60E-15 0.513 −7.328 2.33E-13 0.450 −2.410 0.02 0.752 −1.337 0.18
19 rs1541903 3 71,303,875 71,344,078 T C 0.129 6.111 9.91E-10 0.134 5.939 2.87E-09 0.077 1.228 0.22 0.044 0.842 0.40
20 rs28758576 3 135,476,532 135,602,459 T C 0.898 −5.606 2.08E-08 0.892 −5.305 1.13E-07 0.978 −1.675 0.09 0.968 −0.806 0.42
21 rs34811474 4 25,342,606 25,408,838 A G 0.211 −5.395 6.85E-08 0.223 −5.544 2.95E-08 0.054 −0.454 0.65 0.076 0.640 0.52
22 rs12509393 4 28,273,059 28,347,050 T C 0.255 −5.456 4.87E-08 0.262 −5.188 2.13E-07 0.136 −1.597 0.11 0.325 −0.619 0.54
23 rs10939933 5 61,398,053 61,683,591 C G 0.509 5.956 2.58E-09 0.517 6.161 7.23E-10 0.387 0.358 0.72 0.472 −0.736 0.46
23 rs12521971 5 61,398,053 61,683,591 A C 0.509 5.942 2.81E-09 0.517 6.178 6.49E-10 0.386 0.237 0.81 0.472 −0.739 0.46
24 rs4489042 5 92,362,700 92,538,853 C G 0.401 −5.983 2.19E-09 0.382 −5.610 2.02E-08 0.662 −2.045 0.04 0.554 −0.700 0.48
25 rs6867409 5 103,684,787 104,055,261 T C 0.465 5.961 2.50E-09 0.461 5.973 2.33E-09 0.506 0.688 0.49 0.597 0.352 0.73
25 rs33817 5 103,791,044 104,055,261 A G 0.421 5.942 2.82E-09 0.428 6.358 2.04E-10 0.314 −0.440 0.66 0.451 −0.814 0.42
26 rs295017 5 106,118,410 106,215,439 A G 0.298 5.808 6.31E-09 0.309 5.597 2.19E-08 0.159 1.265 0.21 0.139 1.034 0.30
27 rs13161115 5 106,918,329 107,084,359 C G 0.226 −6.961 3.38E-12 0.238 −6.615 3.72E-11 0.060 −2.664 0.01 0.078 0.767 0.44
27 rs13161130 5 106,918,329 107,060,400 C G 0.232 −6.955 3.54E-12 0.242 −6.650 2.94E-11 0.094 −2.508 0.01 0.081 0.785 0.43
28 rs34425 5 107,349,092 107,769,562 A T 0.317 6.172 6.75E-10 0.307 6.130 8.80E-10 0.475 1.230 0.22 0.170 −0.313 0.75
29 rs175086 5 139,517,197 139,700,608 A G 0.514 6.182 6.35E-10 0.517 5.817 5.99E-09 0.498 1.860 0.06 0.356 1.142 0.25
30 rs251352 5 140,225,137 140,331,337 A G 0.540 −5.581 2.39E-08 0.555 −5.203 1.96E-07 0.354 −1.476 0.14 0.478 −1.961 0.05
31 rs4257818 5 152,505,453 152,610,561 A C 0.388 5.944 2.79E-09 0.405 5.942 2.82E-09 0.198 0.628 0.53 0.164 0.741 0.46
32 rs11167640 5 153,085,668 153,241,171 T C 0.776 5.824 5.75E-09 0.778 5.869 4.39E-09 0.791 0.617 0.54 0.463 0.138 0.89
32 rs13168358 5 153,085,668 153,255,743 T C 0.224 −5.823 5.79E-09 0.222 −5.873 4.27E-09 0.209 −0.594 0.55 0.537 −0.138 0.89
33 rs2135029 5 155,730,681 155,912,474 A G 0.615 −6.812 9.64E-12 0.606 −7.251 4.14E-13 0.774 0.790 0.43 0.435 −0.226 0.82
34 rs11957630 5 164,467,717 164,678,946 A G 0.446 −6.249 4.14E-10 0.458 −5.847 5.01E-09 0.298 −2.021 0.04 0.250 −1.147 0.25
35 rs28986300 6 26,748,873 29,607,101 A G 0.936 −7.468 8.14E-14 0.939 −7.343 2.09E-13 0.908 −1.056 0.29 0.851 −1.334 0.18
35 rs29242 6 25,846,381 29,607,101 T C 0.947 −7.368 1.73E-13 0.946 −7.464 8.39E-14 0.979 −0.272 0.79 0.865 −1.117 0.26
36 rs180963 6 100,914,602 101,339,400 T C 0.493 5.848 4.99E-09 0.496 5.468 4.56E-08 0.465 2.030 0.04 0.383 0.756 0.45
37 rs9479138 6 152,201,201 152,264,529 T G 0.372 7.282 3.30E-13 0.349 7.272 3.54E-13 0.670 1.377 0.17 0.599 −0.668 0.50
38 rs868754 7 1,833,097 2,110,850 C G 0.195 −6.954 3.54E-12 0.205 −6.791 1.11E-11 0.067 −1.506 0.13 0.098 −0.363 0.72
38 rs34809719 7 1,809,618 2,110,850 T G 0.199 −6.943 3.85E-12 0.209 −6.849 7.43E-12 0.067 −1.228 0.22 0.098 −0.372 0.71
39 rs10264275 7 3,521,658 3,715,667 A G 0.763 5.663 1.49E-08 0.762 5.287 1.24E-07 0.796 2.115 0.03 0.618 0.446 0.66
39 rs35791987 7 3,521,658 3,715,667 C G 0.239 −5.653 1.58E-08 0.237 −5.519 3.40E-08 0.247 −1.078 0.28 0.380 −0.670 0.50
40 rs13237518 7 12,233,848 12,285,140 A C 0.435 5.006 5.55E-07 0.414 5.457 4.83E-08 0.689 −0.699 0.48 0.627 −0.445 0.66
41 rs4722031 7 21,468,640 21,555,536 A T 0.294 6.325 2.53E-10 0.308 5.798 6.69E-09 0.117 3.441 0.00 0.228 −1.389 0.16
41 rs2107448 7 21,468,640 21,555,536 T C 0.572 −5.958 2.55E-09 0.581 −5.823 5.78E-09 0.492 −1.725 0.08 0.273 0.846 0.40
42 rs4732514 7 75,607,155 75,852,480 T C 0.645 5.470 4.51E-08 0.660 5.026 5.00E-07 0.425 2.385 0.02 0.575 0.347 0.73
43 rs58043442 7 82,386,297 82,641,937 T C 0.474 −5.753 8.79E-09 0.488 −6.179 6.44E-10 0.278 0.370 0.71 0.394 1.116 0.26
44 rs2470937 7 104,558,434 105,063,372 A T 0.454 6.391 1.65E-10 0.450 6.246 4.22E-10 0.506 1.469 0.14 0.493 0.069 0.95
45 rs1476535 7 113,858,363 114,290,415 T C 0.576 9.183 4.18E-20 0.561 8.807 1.28E-18 0.765 2.564 0.01 0.605 0.589 0.56
46 rs7806900 7 114,940,147 115,113,279 A G 0.535 6.258 3.91E-10 0.519 5.981 2.22E-09 0.769 1.786 0.07 0.531 0.507 0.61
47 rs2214230 7 117,502,574 117,668,235 T G 0.374 6.166 7.01E-10 0.385 5.885 3.98E-09 0.229 1.257 0.21 0.228 1.859 0.06
47 rs61702433 7 117,502,574 117,636,111 T G 0.348 6.053 1.42E-09 0.362 5.994 2.05E-09 0.160 0.507 0.61 0.220 1.568 0.12
48 rs34618371 7 124,392,512 124,710,858 T C 0.607 −5.500 3.80E-08 0.602 −5.054 4.33E-07 0.703 −1.551 0.12 0.553 −2.510 0.01
49 rs10487459 7 126,371,011 126,507,903 A G 0.622 −6.441 1.19E-10 0.612 −6.460 1.05E-10 0.768 −1.219 0.22 0.638 0.912 0.36
50 rs10104247 8 9,397,184 9,641,034 A C 0.814 −5.501 3.77E-08 0.816 −5.462 4.71E-08 0.762 −1.258 0.21 0.906 0.681 0.50
51 rs4129585 8 143,297,329 143,479,815 A C 0.412 6.705 2.02E-11 0.432 6.654 2.85E-11 0.135 1.346 0.18 0.209 −0.438 0.66
52 rs13284172 9 14,578,127 14,688,114 T C 0.628 −5.478 4.29E-08 0.626 −5.211 1.88E-07 0.642 −1.846 0.06 0.783 0.023 0.98
53 rs13290462 9 31,124,452 31,251,063 T G 0.679 5.610 2.02E-08 0.669 6.037 1.58E-09 0.791 −1.095 0.27 0.709 1.196 0.23
54 rs10821163 9 96,106,521 96,386,972 C G 0.339 −7.255 4.00E-13 0.355 −6.915 4.67E-12 0.102 −1.956 0.05 0.313 −1.067 0.29
54 rs10992779 9 96,181,075 96,381,916 A G 0.661 7.131 9.96E-13 0.647 6.982 2.92E-12 0.874 1.239 0.22 0.688 0.970 0.33
55 rs4838242 9 127,765,978 127,898,032 A G 0.470 5.546 2.92E-08 0.472 5.080 3.78E-07 0.410 1.805 0.07 0.674 2.080 0.04
56 rs515805 9 137,932,302 137,965,157 A G 0.185 5.824 5.75E-09 0.187 5.567 2.60E-08 0.144 1.734 0.08 0.238 0.294 0.77
56 rs67736073 9 137,932,302 137,965,157 T C 0.150 5.682 1.33E-08 0.147 5.795 6.84E-09 0.194 0.352 0.72 0.102 0.226 0.82
57 rs1114148 10 67,521,802 67,548,278 T C 0.189 5.674 1.40E-08 0.156 5.384 7.30E-08 0.666 1.469 0.14 0.245 1.222 0.22
58 rs1124372 10 77,537,562 77,660,164 A G 0.730 5.015 5.30E-07 0.720 5.539 3.05E-08 0.858 −1.715 0.09 0.854 1.078 0.28
59 rs2771265 10 93,791,409 94,134,467 T C 0.327 −5.503 3.74E-08 0.343 −5.393 6.94E-08 0.095 −1.023 0.31 0.255 −0.522 0.60
60 rs11192260 10 106,563,924 106,830,537 T C 0.221 −5.571 2.54E-08 0.212 −5.444 5.20E-08 0.370 −1.213 0.23 0.092 −0.239 0.81
60 rs7914674 10 106,563,924 106,830,537 T C 0.755 5.515 3.49E-08 0.789 5.694 1.24E-08 0.252 0.127 0.90 0.894 0.045 0.96
61 rs4350350 11 28,591,168 28,709,434 T C 0.391 −5.813 6.13E-09 0.380 −5.444 5.20E-08 0.564 −2.454 0.01 0.325 0.435 0.66
61 rs11529859 11 28,642,381 28,695,181 T C 0.724 5.278 1.31E-07 0.713 5.579 2.41E-08 0.862 −0.218 0.83 0.877 −0.484 0.63
62 rs488769 11 57,369,008 57,681,828 A C 0.658 −8.577 9.72E-18 0.656 −8.815 1.20E-18 0.653 −0.842 0.40 0.865 1.328 0.18
63 rs559566 11 64,567,047 64,584,231 A G 0.548 −5.665 1.47E-08 0.560 −5.786 7.19E-09 0.364 0.070 0.94 0.612 −1.148 0.25
64 rs7106434 11 112,826,867 113,034,787 T C 0.462 8.125 4.46E-16 0.450 8.410 4.09E-17 0.593 −0.745 0.46 0.674 2.180 0.03
64 rs2186710 11 112,826,867 113,034,787 C G 0.540 −7.992 1.33E-15 0.545 −8.456 2.78E-17 0.501 1.327 0.18 0.328 −1.896 0.06
65 rs10842260 12 24,166,426 24,225,819 A G 0.467 −5.210 1.89E-07 0.466 −5.577 2.44E-08 0.510 0.554 0.58 0.284 0.305 0.76
66 rs2292996 12 103,447,647 103,556,972 T C 0.476 −5.732 9.92E-09 0.496 −5.817 6.00E-09 0.191 −0.355 0.72 0.382 −0.397 0.69
67 rs816363 12 117,649,880 117,700,047 C G 0.580 −5.870 4.37E-09 0.597 −5.762 8.29E-09 0.397 −1.415 0.16 0.334 0.270 0.79
68 rs16948230 12 118,585,698 118,888,131 A G 0.858 −6.637 3.20E-11 0.855 −6.522 6.95E-11 0.894 −1.338 0.18 0.943 −0.197 0.84
68 rs61946067 12 118,585,698 118,888,131 T C 0.862 −6.119 9.44E-10 0.855 −6.536 6.34E-11 0.960 0.960 0.34 0.943 −0.562 0.57
69 rs1373273 13 53,865,141 54,039,629 A C 0.565 −5.838 5.28E-09 0.566 −5.583 2.37E-08 0.544 −0.938 0.35 0.616 −2.310 0.02
70 rs17084460 13 69,561,090 69,687,825 A T 0.916 5.714 1.11E-08 0.919 5.623 1.88E-08 0.858 0.985 0.32 0.963 0.510 0.61
70 rs7333625 13 69,561,090 69,687,825 A T 0.900 5.203 1.96E-07 0.910 5.680 1.34E-08 0.740 −1.397 0.16 0.956 0.790 0.43
71 rs11628299 14 42,036,322 42,697,579 A G 0.448 5.679 1.36E-08 0.427 5.708 1.14E-08 0.760 0.608 0.54 NA NA NA
72 rs57167554 14 47,238,606 47,448,072 A G 0.529 −6.654 2.86E-11 0.524 −6.823 8.91E-12 0.659 −0.022 0.98 0.207 −0.753 0.45
72 rs2899991 14 47,238,606 47,448,072 T C 0.470 6.617 3.67E-11 0.475 6.840 7.91E-12 0.339 −0.153 0.88 0.793 0.655 0.51
73 rs7141058 14 69,429,386 69,765,644 A G 0.472 −5.845 5.08E-09 0.480 −5.987 2.14E-09 0.398 −0.154 0.88 0.205 −0.380 0.70
74 rs11552464 14 103,229,696 103,387,971 T G 0.838 −6.427 1.31E-10 0.834 −6.009 1.86E-09 0.937 −2.548 0.01 0.578 −0.004 1.00
74 rs10132977 14 103,230,005 103,387,971 T C 0.203 6.074 1.25E-09 0.174 6.227 4.74E-10 0.605 0.328 0.74 0.442 −0.092 0.93
75 rs7170398 15 77,995,949 78,146,382 T C 0.400 6.583 4.62E-11 0.412 6.459 1.05E-10 0.254 1.242 0.21 0.307 0.528 0.60
76 rs17514846 15 91,412,850 91,429,042 A C 0.484 −6.925 4.36E-12 0.459 −6.870 6.44E-12 0.801 −1.151 0.25 NA NA NA
77 rs1861188 16 6,310,645 6,345,984 A G 0.654 −5.733 9.88E-09 0.683 −5.514 3.50E-08 0.228 −1.544 0.12 0.680 −0.358 0.72
78 rs6416794 16 51,172,677 51,202,778 T C 0.234 5.572 2.52E-08 0.214 5.252 1.51E-07 0.501 1.474 0.14 0.140 1.405 0.16
79 rs12930480 16 52,232,367 52,327,267 A C 0.821 5.837 5.30E-09 0.811 5.216 1.82E-07 0.950 2.459 0.01 0.923 1.841 0.07
80 rs7200432 16 60,644,510 60,745,208 A G 0.306 5.121 3.03E-07 0.306 5.456 4.87E-08 0.311 −0.573 0.57 0.249 0.049 0.96
81 rs7224932 17 30,173,581 30,571,416 C G 0.165 −5.778 7.55E-09 0.165 −5.599 2.16E-08 0.175 −1.418 0.16 0.148 −0.312 0.75
81 rs143133717 17 30,173,581 30,571,416 T C 0.130 −5.511 3.56E-08 0.139 −5.771 7.87E-09 0.033 0.115 0.91 0.049 −0.154 0.88
82 rs199526 17 43,460,181 44,865,603 C G 0.212 6.820 9.11E-12 0.211 6.414 1.42E-10 0.193 1.927 0.05 0.482 1.609 0.11
82 rs2684641 17 43,460,181 44,865,603 A G 0.824 −6.253 4.03E-10 0.820 −6.646 3.01E-11 0.850 0.450 0.65 0.910 −0.141 0.89
83 rs73338706 17 65,822,573 66,098,979 T C 0.761 −6.435 1.24E-10 0.789 −6.524 6.84E-11 0.406 −0.512 0.61 0.671 −0.399 0.69
84 rs74515851 17 73,431,367 73,497,272 A G 0.044 −5.730 1.00E-08 0.046 −5.323 1.02E-07 0.017 −2.326 0.02 NA NA NA
85 rs7243332 18 26,570,584 26,611,564 A G 0.666 −5.602 2.12E-08 0.680 −5.591 2.26E-08 0.455 −1.043 0.30 0.723 0.431 0.67
86 rs9954874 18 42,843,373 42,843,373 T C 0.594 5.715 1.10E-08 0.573 5.369 7.91E-08 0.898 1.723 0.08 0.641 1.152 0.25
87 rs4632195 18 50,555,225 51,055,069 T C 0.524 7.064 1.62E-12 0.522 7.029 2.07E-12 0.561 1.030 0.30 NA NA NA
88 rs896686 18 53,072,319 53,464,917 T G 0.839 6.232 4.60E-10 0.830 6.195 5.82E-10 0.958 0.820 0.41 0.948 0.584 0.56
89 rs7408312 19 18,412,122 18,444,809 T G 0.440 −5.885 3.98E-09 0.454 −6.072 1.26E-09 0.198 −0.133 0.89 0.690 −0.102 0.92
90 rs13037326 20 44,680,412 44,747,947 T C 0.250 5.724 1.04E-08 0.262 5.590 2.27E-08 0.074 0.642 0.52 0.152 1.806 0.07
90 rs6032660 20 44,680,853 44,749,251 A G 0.763 −5.704 1.17E-08 0.751 −5.744 9.23E-09 0.931 0.059 0.95 0.850 −1.888 0.06
91 rs1378559 X 21,074,049 21,696,222 T C 0.852 5.539 3.05E-08 0.846 5.609 2.04E-08 0.978 −0.484 0.63 0.957 1.178 0.24
92 rs10284205 X 24,914,760 24,927,706 T C 0.591 −5.567 2.59E-08 0.587 −5.513 3.53E-08 0.705 −0.999 0.32 0.605 −0.048 0.96
93 rs1320317 X 117,333,327 117,339,104 T C 0.050 −5.328 9.94E-08 0.031 −5.519 3.40E-08 0.642 0.408 0.68 0.028 −0.108 0.91
94 rs112052534 X 130,428,965 130,432,493 A G 0.696 −5.929 3.05E-09 0.685 −5.971 2.35E-09 0.930 −0.881 0.38 0.861 0.454 0.65
95 rs2266850 X 149,791,188 149,798,641 C G 0.478 5.385 7.26E-08 0.492 5.678 1.36E-08 0.089 −0.219 0.83 0.352 −0.958 0.34

Abbreviations: EA, European ancestry; AA, African ancestry; LAT, Native American (Latin American) ancestry; Chr, chromosome; Start, locus start position in base pairs (GR37 Human Genome Build/h19 coordinates; Stop, locus stop position; A1, coded allele (effects and allele frequencies are coded in terms of copies of this allele); A2, non-coded allele; A, adenosine; C, cytosine; G, guanidine; T, thymidine; A1 Freq, frequency of allele 1.

a

Loci number designations used in manuscript and gene-mapping tables.

b

Where leading marker varied between EA and multi-ancestry, results for both leading markers shown.

c

Results highlighted in color indicate leading SNPs for a specific locus and ancestry.

d

Meta-analysis effect estimates were tested for significance using two-sided z-tests. Results bolded where genome-wide significant (P < 5 × 10−8).