Table 1.
In vitro anti-proliferative activities of 5a–m and 7a–h in different cell lines.
| Compounds | IC50 (µM) a | |||
|---|---|---|---|---|
| A549 | HepG2 | MCF-7 | L-02 | |
| 5a | 14.72 ± 1.54 | 17.12 ± 1.39 | 30.72 ± 1.16 | >50.00 |
| 5b | 15.84 ± 1.50 | 15.22 ± 1.58 | 17.57 ± 2.40 | >50.00 |
| 5c | 20.25 ± 1.46 | 22.54 ± 3.42 | 21.87 ± 2.72 | >50.00 |
| 5d | 8.76 ± 1.56 | 11.04 ± 1.45 | 15.56 ± 1.61 | 30.36 ± 3.44 |
| 5e | 10.71 ± 1.81 | 11.57 ± 1.96 | 14.11 ± 2.35 | 36.68 ± 2.43 |
| 5f | 13.43 ± 2.19 | 18.30 ± 1.36 | 20.71 ± 1.20 | 45.88 ± 2.30 |
| 5g | 15.26 ± 2.40 | 21.10 ± 2.50 | 22.81 ± 2.13 | >50.00 |
| 5h | 18.37 ± 1.13 | 20.18 ± 1.33 | 24.04 ± 2.55 | >50.00 |
| 5i | 14.39 ± 1.42 | 23.65 ± 3.40 | 25.12 ± 3.34 | 38.15 ± 2.82 |
| 5j | 23.30 ± 2.25 | 34.07 ± 3.52 | 32.84 ± 2.95 | >50.00 |
| 5k | 17.16 ± 1.43 | 25.68 ± 2.16 | 26.27 ± 2.30 | >50.00 |
| 5l | 8.30 ± 2.55 | 11.15 ± 1.82 | 15.87 ± 1.90 | >50.00 |
| 5m | 6.85 ± 1.68 | 10.87 ± 1.25 | 12.34 ± 1.11 | 32.51 ± 1.62 |
| 7a | 10.21 ± 1.10 | 13.77 ± 2.19 | 10.80 ± 1.65 | >50.00 |
| 7b | 7.48 ± 1.31 | 10.53 ± 1.68 | 12.76 ± 1.64 | >50.00 |
| 7c | 8.37 ± 1.53 | 12.83 ± 1.73 | 8.35 ± 1.96 | 34.42 ± 4.37 |
| 7d | 6.41 ± 1.90 | 11.54 ± 1.58 | 7.64 ± 2.52 | 35.74 ± 2.66 |
| 7e | 7.12 ± 1.52 | 11.60 ± 1.34 | 9.85 ± 1.53 | >50.00 |
| 7f | 7.38 ± 0.96 | 8.61 ± 1.14 | 8.20 ± 1.21 | >50.00 |
| 7g | 8.60 ± 2.65 | 8.78 ± 1.46 | 13.00 ± 1.52 | >50.00 |
| 7h | 2.16 ± 1.40 | 6.10 ± 1.24 | 6.74 ± 1.94 | >50.00 |
| 4 | 23.83 ± 1.86 | 27.35 ± 0.83 | 25.75 ± 1.14 | 30.25 ± 1.58 |
| Oridonin | 21.10 ± 1.58 | 22.62 ± 1.20 | 18.46 ± 1.37 | 23.62 ± 1.65 |
| Taxol | 4.21 ± 0.73 | 6.60 ± 1.61 | 5.15 ± 0.80 | 8.31 ± 1.82 |
a IC50: Concentration of the tested compound that inhibits 50% of cell growth. All data are recorded as means ± SD of three experiments.