Table 1.

Summary of pharmacological management of non-fertility features of PCOS (adapted from [2].)

Treatment	Description
Combined oral contraceptive pills	For managing hirsutism and irregular menstrual cycles in women and adolescents with PCOS.
Metformin	Suggested to improve metabolic outcomes in persons with PCOS and a BMI > 25 kg/m2. May be explored for cycle control in teenagers and individuals with a BMI < 25 kg/m2 despite weak data. Should be part of lifestyle changes with low-dose administration to reduce adverse effects.
Combination therapy	Combining COCP with metformin offers little additional benefit over either medication alone, except in high metabolic risk groups.
Inositol	For improving metabolic profile.
Anti-obesity drugs	For managing greater weight in PCOS patients, lifestyle therapies and medications such as orlistat, semaglutide, liraglutide, and GLP-1 receptor agonists may be combined.
Anti-androgens	May be used to treat hirsutism in cases where COCP and cosmetic therapy are ineffective, when used with effective contraception.