FIG. 1.

Induction of an antiviral state by HSV-1 KM110 and UV-inactivated wild-type KOS. HEL monolayers were mock infected (mock, IFN) or infected with KM110 (with [+] or without [−] UV inactivation) or UV-inactivated KOS at an MOI of 5. IFN-α was added at 1,000 U/ml following the infection. The next day, ∼100 PFU of VSV was added to each well, and monolayers were stained 24 h later. A similar inhibition of plaquing was observed for HSV-1 KOS and vaccinia virus (data not shown).