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Induction of ISG 56K RNA by V422 is suppressed by loading wild-type VP16 into mutant virions. HEL cells were infected with V422 grown on either U2OS cells (noncomplemented virions) or 16-8 cells (Vero cells that provide VP16 in trans [complemented virions]) at an MOI of 5 (with [+] or without [−] UV inactivation). At 24 h postinfection, RNA was extracted and analyzed for ISG 56K RNA levels by Northern blot hybridization.
