TABLE 1.
Microarray analysis of IFN-treated and HSV-1-infected HEL cells
| Accession no. | Gene or gene product and description | Relative change in level of expression
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| KOS
|
UV-treated KOS
|
KM110
|
IFN-α
|
||||||
| Set A | Set B | Set A | Set B | Set A | Set B | Set A | Set B | ||
| AA193601 | MX1, myxovirus (influenza virus) resistance 1, homolog of murine (IFN-inducible protein p78) | 20.06 | 7.68 | 10.08 | 7.40 | 16.55 | 7.44 | ||
| R82716 | ISG15, IFN-stimulated protein, 15 kDa | 18.33 | 16.53 | 20.46 | 11.83 | 16.55 | 13.88 | ||
| N63988 | EST | 13.69 | 9.1 | 6.25 | 6.21 | ||||
| W52254 | IFIT1, IFN-induced protein 56 | 9.83 | 12.05 | 4.93 | 7.72 | 6.16 | 4.57 | ||
| AA152305 | SCYB10, small inducible cytokine subfamily B (Cys-X-Cys), member 10 | 7.63 | 2.81 | 2.42 | 2.58 | ||||
| W49782 | MX1, myxovirus (influenza virus) resistance 1, homolog of murine (IFN-inducible protein p78) | 6.45 | 4.59 | 3.78 | 3.55 | —a | 5.17 | ||
| AA035361 | STAT1, signal transducer and activator of transcription 1, 91 kDa | 6.33 | 4.13 | 3.94 | 3.48 | 4.37 | 3.08 | ||
| T95113 | Homo sapiens cig5 mRNA, partial sequence | 5.57 | 2.18 | 4 | 1.61 | 2.01 | 1.4 | ||
| R76719 | EST, weakly similar to GEF-2 protein (H. sapiens) | 5.38 | 4.76 | 6.53 | 4.27 | 8.2 | 6.78 | ||
| R09187 | EST | 5.18 | 2.63 | 4.87 | 1.82 | 2.6 | 2.29 | ||
| AA035024 | MX2, myxovirus (influenza virus) resistance 2, homolog of murine | 4.68 | 2.03 | 2.9 | 1.92 | ||||
| T92814 | EST, homolog to H. sapiens cig41 | 4.5 | 2.91 | 3.41 | 3.07 | 2.54 | 2.28 | ||
| H49854 | IFITM1, IFN-induced transmembrane protein 1 (9–27) | 4.43 | 4.49 | 5.69 | 4.41 | 6.69 | 5.38 | ||
| AA046075 | EST | 3.9 | 2.91 | 2.38 | 1.92 | 2.33 | 2.15 | ||
| R59506 | EST, homologue to H. sapiens cyclin-E binding protein | 3.85 | 2.13 | 2.92 | 1.64 | ||||
| AA043535 | IMAGE-487558 | 3.31 | 1.98 | 2.34 | 2.14 | 2.46 | 2.15 | ||
| W47619 | OAS3, 2′→5′ oligoadenylate synthetase 3 | 2.99 | 2.13 | 2.73 | 2.26 | 2.13 | 2.46 | ||
| N63887 | EST, weakly similar to TYKi protein (Mus musculus) | 2.81 | 1.75 | 2.21 | 1.67 | ||||
| N43008 | SP100, nuclear antigen Sp100 | 2.81 | 1.91 | 2.23 | 1.77 | 2.38 | 2.38 | ||
| T74462 | ABCB2, ATP-binding cassette, subfamily B (MDR/TAP), member 2 | 2.77 | 2.03 | 2.44 | 1.4 | 2.21 | 1.67 | ||
| R34567 | OAS2, 2′→5′ oligoadenylate synthetase 2 | 2.59 | 1.93 | 2.3 | 1.71 | 2.21 | 2.45 | ||
| H70440 | GS3686, hypothetical protein, expressed in osteoblast | 2.48 | 2.06 | 3.29 | 1.41 | 2.28 | 1.95 | ||
| T86070 | EST | 2.42 | 1.88 | 2.08 | 1.66 | ||||
| R23341 | B2M, β-2-microglobulin | 2.3 | 1.91 | 3.09 | 1.94 | 2.83 | 2.29 | ||
| W94862 | ADAR, adenosine deaminase, RNA specific | 2.29 | 1.94 | 2 | 1.95 | ||||
| AA028065 | BRF2, butyrate response factor 2 (EGF-response factor 2) | 2.25 | 1.93 | ||||||
| W47350 | RARRES3, retinoic acid receptor responder (tazarotene induced) 3 | 2.13 | 1.97 | 2.03 | 1.95 | ||||
| T80567 | KIAA072, KIAA0725 protein | 2.02 | 1.74 | 2.31 | 1.5 | ||||
| AA001748 | EST, weakly similar to angiopoietin Y1 (H. sapiens) | 2.01 | 2.35 | ||||||
| AA040506 | IMAGE-485950 | 2 | 1.75 | ||||||
| AA040032 | KIAA0015, KIAA0015 gene product | 0.55 | 0.36 | 1.99 | 2.37 | 2.04 | 2.18 | 3.37 | 3.59 |
| W63787 | PHGDH, β-phosphoglycerate dehydrogenase | 0.42 | 0.5 | ||||||
| R13977 | EST | 0.37 | 0.43 | 0.52 | 0.47 | ||||
| R80595 | SOD2, superoxide dismutase 2, mitochondrial | 3.7 | 1.81 | ||||||
| H60340 | IMAGE-207631 | 1.78 | 2.08 | ||||||
| H17813 | TOP2A, topoisomerase II alpha | 0.48 | 0.48 | ||||||
| R40483 | Homo sapiens clone 24877 mRNA sequence | 3.31 | 1.85 | ||||||
| N34456 | NT5, 5′ nucleotidase (CD73) | 2.19 | 1.83 | ||||||
| AA040062 | EST, weakly similar to yeast antiviral protein SK12 and ATP-dependent DNA helicase | 3.65 | 1.48 | 2.84 | 2.14 | 2 | 1.59 | ||
| N58703 | IMAGE-247579 | 2.1 | 1.51 | 2.15 | 1.89 | ||||
| W88741 | EST | 5.41 | 44.08 | ||||||
| N30287 | EST, weakly similar to Wiscott-Aldrich syndrome protein homolog | 2.32 | 2.58 | ||||||
| W67568 | HLA-A, MHC class I, A | 0.43 | 0.18 | 2.64 | 3.21 | ||||
| AA053162 | HLA-B, MHC class I, B | 2.42 | 2.32 | ||||||
| W00378 | HLA-C, MHC class I, C | 2.22 | 2.43 | ||||||
a
—, Intensity of the spot on the array was below local background.