Table 3.
Top 10 DE Anionic & Cationic Metabolite in Adult MMD Vs Adult HC
| Compound | FC | log2FC | P-value | VIP | Up/Down | |
|---|---|---|---|---|---|---|
| Anionic metabolites | ||||||
| Indole-3-acrylic acid | 2.55 | 1.35 | 0.049 | 1.66 | up | |
| Dimethyl 4-Hydroxyisophthalate | 2.43 | 1.28 | 0.000 | 2.81 | up | |
| Lignoceric Acid | 2.34 | 1.23 | 0.016 | 1.51 | up | |
| Traumatic acid | 2.27 | 1.18 | 0.020 | 1.56 | up | |
| Capric acid | 2.10 | 1.07 | 0.042 | 2.00 | up | |
| N-{6-[4-(tert-butyl)phenoxy]-3-pyridinyl}-4-(trifluoromethyl)benzamide | 0.07 | −3.87 | 0.033 | 2.23 | down | |
| (±)18-HEPE | 0.15 | −2.76 | 0.040 | 1.76 | down | |
| beta-Nicotinamide mononucleotide | 0.23 | −2.13 | 0.010 | 2.35 | down | |
| PC (4:0/18:5) | 0.23 | −2.09 | 0.021 | 1.50 | down | |
| N1-(1,3-diphenyl-1H-pyrazol-5-yl)-2-chlorobenzamide | 0.25 | −2.02 | 0.009 | 2.36 | down | |
| Cationic metabolites | ||||||
| 2-[3-(4-pyridyl)-1H-1,2,4-triazol-5-yl]pyridine | 56.64 | 5.82 | 0.007 | 2.43 | up | |
| 4-morpholinobenzoic acid | 22.59 | 4.50 | 0.005 | 2.49 | up | |
| N-Acetyl-L-tyrosine | 10.71 | 3.42 | 0.004 | 2.45 | up | |
| N-[1-(4-methoxy-2-oxo-2H-pyran-6-yl)-2-methylbutyl]acetamide | 10.20 | 3.35 | 0.004 | 2.57 | up | |
| bicyclo[2.2.2]oct-2-en-1-yl 4-methylbenzene-1-sulfonate | 3.63 | 1.86 | 0.009 | 1.98 | up | |
| PC (20:5e/17:2) | 0.04 | −4.68 | 0.041 | 2.06 | down | |
| 2-[5-(2-hydroxypropyl)oxolan-2-yl]propanoic acid | 0.17 | −2.52 | 0.037 | 1.98 | down | |
| 5-ethoxy-2-[(2,3,4,5,6-pentafluorobenzyl)thio]-1H-benzo[d]imidazole | 0.41 | −1.28 | 0.007 | 1.51 | down | |
| PC (18:5e/2:0) | 0.45 | −1.15 | 0.036 | 1.78 | down | |
| PC (17:1/18:2) | 0.53 | −0.91 | 0.002 | 2.45 | down | |