Table 1.
Prioritization of the top 5 lipid-related traits for dementia, AD, and VaD.
| Metabolite Traits | Rank | MIP | Average Effect | Empirical p Values |
|---|---|---|---|---|
| Dementia | ||||
| Concentration of very large HDL particles | 1 | 0.139 | −0.025 | 0.002 |
| Mean diameter for HDL particles | 2 | 0.127 | −0.018 | 0.005 |
| Free cholesterol in very large HDL particles | 3 | 0.116 | −0.02 | 0.097 |
| Phospholipids in very large HDL particles | 4 | 0.110 | −0.015 | 0.028 |
| Total lipids in very large HDL particles | 5 | 0.084 | −0.007 | 0.059 |
| AD | ||||
| Total cholesterol in very large HDL particles | 1 | 0.579 | −0.094 | 0.005 |
| Serum total cholesterol | 2 | 0.101 | −0.031 | 0.084 |
| Free cholesterol to esterified cholesterol ratio | 3 | 0.062 | 0.012 | 0.291 |
| Glycoprotein acetyls | 4 | 0.044 | 0.005 | 0.628 |
| Phospholipids in medium LDL particles | 5 | 0.044 | 0.007 | 0.985 |
| VaD | ||||
| Omega-7, omega-9 and saturated fatty acids | 1 | 0.311 | −0.13 | 0.012 |
| Serum total cholesterol | 2 | 0.186 | −0.103 | 0.001 |
| Triglycerides in very large HDL particles | 3 | 0.101 | −0.02 | 0.026 |
| Total cholesterol in medium LDL particles | 4 | 0.101 | 0.039 | 0.012 |
| Total cholesterol in LDL particles | 5 | 0.1 | 0.041 | 0.007 |
MIP: Marginal inclusion probability; AD: Alzheimer’s disease; VaD: vascular dementia.