Table 2.
Models of lipid-related traits for dementia, AD, and VaD.
| Model | Posterior Probability | Causal Estimate |
|---|---|---|
| Dementia | ||
| Mean diameter for HDL particles | 0.055 | −0.109 |
| Concentration of very large HDL particles | 0.054 | −0.124 |
| Phospholipids in very large HDL particles | 0.047 | −0.112 |
| Free cholesterol in very large HDL particles | 0.042 | −0.126 |
| Total lipids in very large HDL particles | 0.029 | −0.115 |
| Cholesterol esters in large HDL particles | 0.028 | −0.113 |
| Concentration of large HDL particles | 0.027 | −0.112 |
| Total lipids in large HDL particles | 0.026 | −0.112 |
| Total cholesterol in large HDL particles | 0.025 | −0.114 |
| Free cholesterol in large HDL particles | 0.023 | −0.114 |
| Concentration of small HDL particles | 0.020 | 0.161 |
| AD | ||
| Total cholesterol in very large HDL particles | 0.362 | −0.161 |
| VaD | ||
| Triglycerides in very large HDL particles | 0.028 | −0.170 |
| Omega-7, omega-9 and saturated fatty acids | 0.025 | −0.246 |
AD: Alzheimer’s disease; VaD: vascular dementia.