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Transcriptional activation by the HCV C protein is abrogated by depletion of calcium. Jurkat cells were cotransfected with NFAT-luc and either pOP/HCV1-194 (HCV1-194), negative control pOPCMV/ct(−), or pBJ5-CNMUT2B (CNmutB). One hour before stimulation with TPA, one half of each set of cells was shifted to calcium-deficient medium containing 2 mM EGTA. At 7 h poststimulation, luciferase activity was determined.
