Table 1.
List of the BMI-related SNPs (n = 10) investigated for associations in the iMPROVE cohort.
| Consortial Summary Statistics | iMPROVE Cohort |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP | Gene | Chr | Position (bp) | Alleles | MAF | Effect Allele | Direction of Effect for BMI | MAF | Ref |
| rs6548238_T | LINC01875, TMEM18 | 2 | 2:634905 | T/C/G | 0.12 (T) | C | Positive | T: 0.095 | GWAS Catalog |
| rs1801282_G | PPARG | 3 | 3:12351626 | C/G | 0.07 (G) | G | Positive | G: 0.053 | GWAS Catalog |
| rs2241766_G | APIPOQ | 3 | 3:186853103 | T/A/C/G | 0.15 (G) | G | Positive | G: 0.45 | GWAS Catalog |
| rs925946_T | BDNF | 11 | 11:27645655 | T/A/C/G | 0.25 (T) | T | Positive | T: 0.103 | GWAS Catalog |
| rs1421085_C | FTO | 16 | 16:53767042 | T/C | 0.23 (C) | C | Positive | C: 0.26 | GWAS Catalog |
| rs1121980_A | FTO | 16 | 16:53775335 | G/A/C | 0.37 (A) | A | Positive | A: 0.28 | GWAS Catalog |
| rs17817449_G | FTO | 16 | 16:53779455 | T/A/G | 0.31 (G) | G | Positive | G: 0.28 | GWAS Catalog |
| rs3751812_T | FTO | 16 | 16:53784548 | G/T | 0.22 (T) | T | Positive | T: 0.25 | GWAS Catalog |
| rs9939609_A | FTO | 16 | 16:53786615 | T/A | 0.34 (A) | A | Positive | A: 0.26 | GWAS Catalog |
| rs17782313_C | MC4R | 18 | 18:60183864 | T/A/C | 0.24 (C) | C | Positive | C: 0.13 | GWAS Catalog |
BMI: Body Mass Index, SNP: Single nucleotide polymorphism, Chr: chromosome, bp: base pairs, MAF: minor allele frequency (as shown in GWAS Catalog), Ref: reference.