Figure 2:

Dose response for MCF-7 and T-47D lines confronted to chemotherapy (doxorubicin and paclitaxel) in combination with disulfiram. A, MCF-7 dose response for chemo alone (black) and combination with disulfiram (gray). B, Synergy is calculated using MUSYC dose response framework¹¹ for treatment-naive line. repeated for C, doxorubicin evolved-resistant line and D, paclitaxel evolved-resistant line. E-H, Disulfiram investigation repeated for T-47D. Synergistic potency (a₁₂, a₂₁) and efficacy ($\beta$) are shown in Table 1.