Figure 4:

Fitness parameters determine selection dynamics: A, MCF7 sensitive and doxorubicin-resistant lines, Left (relative fitness): fitness functions fit in figure 3, shown across all monotherapy or combination therapy options. Relative fitness of sensitive (parameters B - D) and resistant (parameters C - A) shown. Middle (selection dynamics): relative fitness plotted in a quadrant showing selection dynamics as a function of B - D and C-A. All treatment scenarios select for sensitive to varying degrees. Right (tumor fitness): overall tumor fitness of mixed populations shown (long-term model prediction; see Methods). High dose combination therapy minimizes tumor fitness. B, relative fitness, selection dynamics, and tumor fitness are shown for MCF7 sensitive and paclitaxel-resistant cell lines. C, relative fitness, selection dynamics, and tumor fitness are shown for T47D sensitive and paclitaxel-resistant cell lines.