Figure 4. Metient identifies more polyclonality and polyphyelticity in a large-scale NSCLC cohort.

(a) The top two Pareto-optimal solutions for NSCLC patient CRUK0484 as ranked by Metient-calibrate. Comparison of Metient’s inference to TRACERx’s: (b) clonality and (c) phyleticity classification. Counts indicate the number of patients in agreement or disagreement. (d) All Pareto-optimal solutions for NSCLC patient CRUK0762 as ranked by Metient-calibrate. (f) Patient CRUK0762 where seeding pattern and clonality are in agreement between TRACERx and Metient-calibrate but phyleticity differs due to which clones are classified as seeding.