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[Preprint]. 2024 Sep 5:2024.09.04.611172. [Version 2] doi: 10.1101/2024.09.04.611172

Fig. 3. MLX phosphorylation is required for the binding of ChREBP-MLX heterotetrametric complex on the ChoRE.

Fig. 3.

a-b. A model of ChREBP-MLX (a) and ChREBP-pMLX (b) structure on the PK ChoRE by AlphaFold 3.

c. Sequences of single E-box, perfect-ChoRE or PK-ChoRE probes.

d. Binding of ChREBP and/or MLX to single E-box, perfect-ChoRE or PK-ChoRE probes.

e-h. Quantification in d. One-way ANOVA or t-test, **p<0.01***p<0.001 ns=not significant. N=3–4.