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[Preprint]. 2024 Sep 5:2024.09.04.611172. [Version 2] doi: 10.1101/2024.09.04.611172

Fig. 6. CK2/GSK3-mediated MLX phosphorylation stabilizes the heterotetrametric ChREBP-MLX complex on the ChoRE to promote sugar response.

Fig. 6.

CK2 and GSK3 phosphorylate MLX in response to G6P availability. G6P accumulation inhibits MLX phosphorylation. Phosphorylated MLX stabilizes the heterotetrametric ChREBP-MLX complex on the ChoRE, promoting transcriptional activity and sugar response.