Figure 1. Generation of multi-omics datasets for 117 study participants.

Contestants were provided with training datasets containing two cohorts (datasets 2020 and 2021), while the prediction dataset contained a newly generated cohort (dataset 2022). The training datasets contain pre-vaccination and post-vaccination immune response data, whereas the prediction dataset for 21 participants only contains pre-vaccination immune response data. Post-vaccination data was released after the challenge ended and used to evaluate submitted models.