Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

[Preprint]. 2024 Oct 3:2024.09.06.611729. [Version 3] doi: 10.1101/2024.09.06.611729

PMC11398526.2; 2024 Sep 8
PMC11398526.3; 2024 Oct 3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.

PMC Copyright notice

Extended Data Fig. 2 — A. XiView images of differential XL-MS data for PR-A vs. PR-A:SRC3 experiments with crosslinks enriched in apo samples (top) and pre-bound samples (bottom) represented. HDX overlays are indicative of their comparable differential HDX-MS experiments. Top: SRC3 exchange - SRC3 vs. PR-A:SRC3 (non-DNA bound), PR exchange – PR-A vs. PR-A:SRC3. Bottom: SRC3 exchange – SRC3 vs. PR-A:SRC3:PRE, PR exchange – PR-A:SRC3 vs. PR-A:SRC3:PRE. B. XiView images of differential XL-MS data for PR-B vs. PR-B:SRC3 experiments with the same HDX overlays as shown in A. Intraprotein crosslinks are represented in purple, interprotein crosslinks are represented as green. Differential HDX-MS scale shows the % change in deuterium incorporation, where cooler colors represent reduced deuterium exchange, while warmer colors (yellow, orange, red) represent increased deuterium exchange. Black represents peptides not detected in HDX-MS experiments, and PR isoforms have numbering normalized to the B isoform.