Table 1.
Demographic of participants
| ADRC | Overall | Negative Control§ | Probable AD§ | p-value* | ||||
|---|---|---|---|---|---|---|---|---|
| Count | 30 | 22 | 8 | |||||
| Sex (% Female) | 16 (53.3) | 12 (54.5) | 4 (50.0) | 1.000 | ||||
| Age (SD), year | 75.6 (7.8) | 75.3 (8.1) | 76.6 (5.2) | 0.530 | ||||
| APOE ε4 carrier (%) | 9 (30.0) | 5 (22.7) | 4 (50.0) | 0.200 | ||||
| MoCA score (mean (SD)) | 22.9 (7.3) | 26.5 (2.2) | 11.9 (6.7) | <0.001 | ||||
| MMSE score (mean (SD)) | 24.7 (6.3) | 27.6 (2.5) | 16.9 (7.1) | <0.001 | ||||
| CDR = 0 (%) | 9 (30.0) | 9 (40.9) | 0 (0.0) | <0.001 | ||||
| CDR = 0.5 (%) | 16 (53.3) | 11 (50.0) | 5 (62.5) | |||||
| CDR = 1 (%) | 3 (10.0) | 2 (9.1) | 1 (12.5) | |||||
| CDR = 2 (%) | 2 (6.7) | 0 (0.0) | 2 (25.0) | |||||
| AGUEDA | Overall | Aβ-PET-negative§ | Ap-PET-positive§ | p-value* | <12 CL | 12–24 CL | >24 CL | p-value* |
| Count | 77 | 59 | 18 | 59 | 6 | 12 | ||
| Sex (% Female) | 44 (57.1) | 33 (55.9) | 11 (61.1) | 0.907 | 33 (55.9) | 4 (66.7) | 7 (58.3) | 0.876 |
| Age (SD), year | 71.4 (3.9) | 71.0 (4.0) | 72.7 (3.3) | 0.104 | 71.0 (4.0) | 73.6 (3.6) | 72.3 (3.1) | 0.216 |
| Education (mean (SD)), year | 11.7 (4.8) | 11.5 (5.0) | 12.1 (4.2) | 0.661 | 11.5 (5.0) | 14.0 (4.1) | 11.2 (4.1) | 0.453 |
| APOE ε4 carrier (%) | 12 (16.0) | 7 (12.1) | 5 (29.4) | 0.181 | 7 (12.1) | 0 (0.0) | 5 (41.7) | 0.024 |
| MOCA score (mean (SD)) | 25.8 (2.2) | 25.8 (2.3) | 25.9 (1.9) | 0.737 | 25.8 (2.3) | 26.5 (2.0) | 25.7 (18) | 0.709 |
| MMSE score (mean (SD)) | 28.9 (11) | 28.9 (1.0) | 29.1 (1.4) | 0.592 | 28.9 (1.0) | 29.7 (0.5) | 28.8 (1.7) | 0.206 |
| Centiloid (mean (SD)) | 7.5 (25.2) | −3.7 (8.25) | 16.0 (3.0) | 58.2 (22.3) | <0.001 |
Mean and Standard Deviation are reported for continuous variables. Frequencies and percentages are shown for categorical variables.
§
The diagnosis was performed by clinical diagnosis for ADRC cohort, and Aβ PET neuroimaging for AGUEDA cohort.
*
P-values were calculated using the Wilcoxon Rank Sum or Kruskal-Wallis tests for continuous variables, and Fisher’s exact test for a categorical variable.
Two participants had missing data for APOE alleles. The percentage was calculated based on a sample size of 75.
Abbreviations: APOE, apolipoprotein E; CDR, Clinical Dementia Rating; MMSE, Mini Mental State Examination; MoCA, Montreal Cognitive Assessment; CL, Centiloid.