(A) Representative heatmaps of time spent in each area of the open field arena for one mouse of each genotype, age, and sex. (B-I) Individual (circles) and mean ± SEM (black bars) of the number of center entries (B,C), total open field center time (D, E), total freezing duration during open field exploration (F, G), and total number of fecal boli at the end of open field exploration (H, I) for each genotype at both ages (B, D, F, and H) and further separated by sex (C, E, G, and I). (J) Representative heatmaps of time spent in each area of the zero maze for one mouse of each genotype, age, and sex. (K-N) Individual animal (circles) and group mean ± SEM (black bars) of total open arm center time (K, L) and the number of open arm entries (M, N) in the elevated zero for each genotype at both ages (K, M) and further separated by sex (L, N). For A, and J, the color scale bar at right applies to all heatmaps in the corresponding assay. N = 22–30 mice/group for each genotype at each age and N = 10–16 mice/group for each sex within each genotype at each age. *p<0.05 for post-hoc test between genotypes with a Bonferroni correction.