Table 1.
Comparison of studies demonstrating behavioral changes in shank3 mutant mouse models with age.
| Publication | Ferhat et al., 2023 | Bauer et al., 2023 | Thabault et al., 2023 | Contestabile et al., 2023 | Kshetri et al.. Current Study | |
|---|---|---|---|---|---|---|
| Model | Δ11 | Δ11 | Δ21 | Δ4–22 | Δ4–22 | |
| Isoforms Deleted | a,b,c | a,b,c | a,c,d,e,f | a,b,c,d,e,f | a,b,c,d,e,f | |
| Testinq Liqht Cycle | Light | N/A | N/A | Light | Dark | |
| Aqes (weeks) | 12, 32, 52 | 4–9, 13–18 | 10, 20,40 | 2–8 | 5–7, 12–20 | |
| Separate Aqe Cohorts | Y/N | N | Y | N/A | Y | |
| Sexes | M/F | M/F | M/F | M/F | M/F | |
| Motor Function | Rotarod | ↓ | ↓ | ↓ | ||
| Beam Balance | ↓ | |||||
| Gait | – | |||||
| Speed | – | |||||
| Strength | ↓ | |||||
| Social | 3 Chamber or Free Social Preference | – | – | ↓ | ↓ | |
| 3 Chamber Social Novelty | – | |||||
| Sociosexual | ↑ | |||||
| Ultrasonic Vocalizations | – | – | ||||
| Exploratory | Locomotion | ↓ | ↓ | – | ↓ | |
| Marble Burying | ↓ | ↓ | ||||
| Anxiety-like | Open Field Center Time | ↓ | ↓ | ↓ | ||
| Zero/Plus Maze Open Arm Time | – | ↓ | ↓ | |||
| Repetitive/Stereotyped | Grooming | ↑ | ↑ | ↑ | ↑ | |
| Rearing | ↑ | |||||
| Nestlet Shreddinq | ↑ | |||||
| Memory | Y-Maze | – | – | |||
| Barnes/Star Maze | – | – |
Abbreviations: Y = Yes, N = No, N/A = Not available, M = Male, F = Female, ↑ = increase, ↓ = decrease, - = no change in tested behaviors due to reduced shank expression