Figure 2. TCIA non-pCR patient tested using the DCE-to-PK cGAN.

Two representative DCE MRI slices from a non-pCR patient revealed highly enhanced tumor lesions at both pre-treatment (V1) and post-NACT (V2). Notably, ETM and cGAN K_trans maps showed excellent spatial correlation and high structural similarity (a). Quantification of tumor mean K_trans at V1 (n = 22 slices) and V2 (n = 21 slices) revealed a small decrease in vascular permeability at V2 by both the ETM and cGAN (b). Analysis of slice-based mean K_trans (c) and pixel-by-pixel K_trans (d) showed strong correlations (R² = 0.98) between the cGAN and ETM (p < 0.0001). Mean ± SD.