FIG. 1.

MV genome map. The location of protein coding regions (white boxes: N, P, V, C, M, F, H, and L) and noncoding regions including the leader and trailer (black terminal boxes) and intergenic regions (shaded blue) are shown, along with specialized sequence motifs (2, 16, 19, 27, 41, 52). The TCRs at the 3′ end of the genomic RNA (leader TCR, nucleotides 1 to 107) and the 3′ end of the antigenomic RNA (trailer TCR, nucleotides 15785 to 15894) are enlarged below the genome map. Genomic RNA synthesis initiation is shown as open arrowheads in the enlargement of the leader and trailer TCR regions. Sequence motifs shown in the expanded TCR maps include the leader, trailer, GE and GS signals, the 16-base conserved terminal sequence (shown 3′ to 5′), the repeated B- and B'-box motif, the G(N)5 motif, the ATG codon for the N gene adjacent to the leader, and the L protein stop codon outside of the 5′ end of the trailer. The positions of GE/GS signals are designated with a combination of solid arrowhead (GS) and a black box (GE). The leader TCR GE/GS symbol lacks a GE box, and the trailer TCR GE/GS lacks a GS arrowhead to signify that these sequences may not function identically to GE/GS elements in the intergenic regions. The mRNA editing site is indicated below the V protein coding region (6). Part of the F gene mRNA 5′-untranslated nucleotide sequence is shown to illustrate the three in-frame AUG initiator codons (5). At the bottom of the figure, several symbols found in the TCR maps are defined.