TABLE 5.

Partial absence of virus nucleic acid in the nervous tissue of BDV-infected rats treated with anti-gp94 neutralizing monoclonal antibody after infection

Viral component	Area found	Viral component presence in:
		Control rats	Antibody-treated ratsa
Antigenb	Forebrain	+, +, +
	Cerebellum	+, +, +	−, −, −
	Thoracal spinal cord	+, +, +	−, −, −
	Lumbar spinal cord	+, +, +	−, −, −
Nucleic acidc	Forebrain	+, +, +	−, −, −
	Cerebellum	+, +, +	+,d +, +
Infectious virus (log10 virus titer)	Forebrain	<1.8, 4.3, 4.5	<1.8, <1.8, <1.8
	Cerebellum	<1.8, 3.7, 4.2	<1.8, <1.8, <1.8
	Thoracal spinal cord	3.6, 5.0, 4.3	<1.8, <1.8, <1.8
	Lumbar spinal cord	5.0, 4.3, 4.2	<1.8, <1.8, <1.8

^aTreatment was given 1 h prior to and once a week after BDV infection. Rats were killed 28 days after infection. 

^bDetected by Western blotting. 

^cDetected by in situ hybridization. 

^dOnly a few infected cells.