TABLE 6.

Absence of virus in nervous tissue in BDV-infected rats treated with anti-gp94 neutralizing monoclonal antibody prior to infection

Viral component	Area found	Viral component presence in:
		Control rats	Antibody-treated ratsa
Antigenb	Forebrain	+, +, +
	Cerebellum	+, +, +	−, −, −
	Thoracal spinal cord	+, +, +	−, −, −
	Lumbar spinal cord	+, +, +	−, −, −
Nucleic acidc	Forebrain	+, +, +	−, −, −
	Cerebellum	+, +, +	−, −, −
Infectious virus (log10 virus titer)	Forebrain	6.8, 4.6, 7.5	<1.8, <1.8, <1.8
	Cerebellum	3.9, 3.6, 4.3	<1.8, <1.8, <1.8
	Thoracal spinal cord	5.3, 4.9, 4.9	<1.8, <1.8, <1.8
	Lumbar spinal cord	3.3, 3.9, 4.3	<1.8, <1.8, <1.8

^aTreatment was given 3 days and 1 day prior to and every 7 days after BDV infection until day 28 p.i. Rats were killed on day 35 p.i. 

^bDetected by Western blotting. 

^cDetected by in situ hybridization.