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. 2024 Aug 23;13(8):1592–1601. doi: 10.21037/tau-24-153

Table 2. Relevant important references.

Author(s) Title Journal Year
Han LJ, He XF, Ye XH (21) Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis Medicine (Baltimore) 2020
Aliakbari F, Pouresmaeili F, Eshghifar N, et al. (22) Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis Reprod Biol Endocrinol 2020
Wu W, Shen O, Qin Y, et al. (23) Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta-analysis Int J Androl 2012
Clément A, Amar E, Brami C, et al. (24) MTHFR SNPs (Methyl Tetrahydrofolate Reductase, Single Nucleotide Polymorphisms) C677T and A1298C Prevalence and Serum Homocysteine Levels in >2100 Hypofertile Caucasian Male Patients Biomolecules 2022
Colacurci N, De Leo V, Ruvolo G, et al. (25) Recombinant FSH Improves Sperm DNA Damage in Male Infertility: A Phase II Clinical Trial Front Endocrinol (Lausanne) 2018
Liu Y, Zhang F, Dai L (26) C677T polymorphism increases the risk of early spontaneous abortion J Assist Reprod Genet 2019
Xin Z, Han N, Jin H (27) Correlation analysis of age and MTHFR C677T polymorphism with sperm motility and sperm DNA integrity Cell Mol Biol (Noisy-le-grand) 2023
Safarinejad MR, Shafiei N, Safarinejad S (28) Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility Reprod Sci 2011
Xie C, Ping P, Ma Y, et al. (29) Correlation between methylenetetrahydrofolate reductase gene polymorphism and oligoasthenospermia and the effects of folic acid supplementation on semen quality Transl Androl Urol 2019
Martínez Duncker Rebolledo E, Chan D, Christensen KE, et al. (30) Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation Mol Hum Reprod 2024
Clement A, Amar E, Clement P, et al. (31) Hyperhomocysteinemia in hypofertile male patients can be alleviated by supplementation with 5MTHF associated with one carbon cycle support Front Reprod Health 2023
Huang WJ, Lu XL, Li JT, et al. (32) Effects of folic acid on oligozoospermia with MTHFR polymorphisms in term of seminal parameters, DNA fragmentation, and live birth rate: a double-blind, randomized, placebo-controlled trial Andrology 2020
Safarinejad MR, Safarinejad S, Shafiei N (33) Role of methylenetetrahydrofolate reductase gene polymorphisms (C677T, A1298C, and G1793A) in the development of early onset vasculogenic erectile dysfunction Arch Med Res 2010
Bai S, Li MZ, Wan YY, et al. (34) Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic Asian J Androl 2024
Šerý O, Šrámková T, Klempová J, et al. (35) The relationship between the C677T polymorphism of the MTHFR gene and serum levels of luteinizing hormone in males with erectile dysfunction Neuro Endocrinol Lett 2012
Lombardo F, Sgrò P, Gandini L, et al. (36) Might erectile dysfunction be due to the thermolabile variant of methylenetetrahydrofolate reductase? J Endocrinol Invest 2004
Lombardo F, Tsamatropoulos P, Piroli E, et al. (37) Treatment of erectile dysfunction due to C677T mutation of the MTHFR gene with vitamin B6 and folic acid in patients non responders to PDE5i J Sex Med 2010
Wang CH, Huang YF (38) Hyperhomocysteinemia and erectile dysfunction: an update Zhonghua Nan Ke Xue 2011