Table 3.

Multivariable Logistic Regression Model for Predictors (Domain-Level) Associated With the Binary AAO Outcome in Cohort 2

	Parameter	OR	95% CI	p Value
Model 1
Pathology	CSF p-tau181 levels	1.014	0.983–1.046	0.38
IPIP (collateral-reported)	Conscientiousness	0.916	0.845–0.994	0.04
Model 2
Cognition	MMSE scores	0.376	0.139–1.019	0.055
IPIP (collateral-reported)	Conscientiousness	0.908	0.835–0.986	0.02
Model 3
Cognition	MMSE scores	0.379	0.139–1.029	0.057
Pathology	CSF p-tau181 levels	1.015	0.978–1.053	0.43
IPIP (collateral-reported)	Conscientiousness	0.914	0.836–1.000	0.051
Model 4
Years of education	Years of education	0.474	0.249–0.902	0.02
IPIP (collateral-reported)	Conscientiousness	0.880	0.799–0.969	0.009

Abbreviations: AAO = age at symptom onset; IPIP = International Personality Item Pool; MMSE = Mini-Mental State Examination; OR = odds ratio.

Model 1 was adjusted for CSF p-tau181 levels. Model 2 was adjusted for MMSE scores. Model 3 was adjusted for MMSE scores and CSF p-tau181 levels. Model 4 was adjusted for years of education. The p values were obtained from a multivariable logistic regression model used to regress the event (equal or earlier AAO than parental AAO, negative outcome) or control (delayed AAO, positive outcome) status. Statistical significance (p < 0.05) is indicated by bold font.