TABLE 3.
Effects of mutations in the VP1 hook region
| Mutation | Sequence surrounding mutationa | Virus | Reference | Phenotype |
|---|---|---|---|---|
| A30G | SVPALTAVETGHTSQVT | CAV9 | This study | Labile virion |
| A30S | SVPALTAVETGHTSQVT | CAV9 | This study | Somewhat labilized virion |
| T32S | SVPALTAVETGHTSQVT | CAV9 | This study | Stabilized virion |
| V34A | SVPALTAVETGHTSQVT | CAV9 | This study | Labile virion |
| V34I | SVPALTAVETGHTSQVT | CAV9 | This study | Somewhat labilized virion |
| A43V | EIPALTAVETGATNPLV | PV1 | 7 | Neurovirulence determinant (mouse) |
| E40G | ETPALTAVETGATNPLV | PV2 | 22 | Host range determinant (mouse) |
| P54S | ETPALTAVETGATNPLV | PV2 | 22 | Host range determinant (mouse) |
| A49V | EVPALTAVETGATNPLA | PV3 | 23 | Hyperlabile virion (WIN-resistant) |
| N51S | EVPALTAVETGATNPLA | PV3 | 23 | Hyperlabile virion (WIN-resistant) |
| P52S | EVPALTAVETGATNPLA | PV3 | 23 | Hyperlabile virion (WIN-resistant) |
| A54T | EVPALTAVETGATNPLA | PV3 | 21 | Suppressor of ts phenotype |
| A54V | EVPALTAVETGATNPLA | PV3 | 21 | Suppressor of ts phenotype |
a
Mutated position shown in boldface type.